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| Status |
Public on Jul 02, 2024 |
| Title |
Disease-associated microglia signature genes are up-regulated during photoreceptor degeneration |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Retinal degeneration is a collection of devastating conditions with progressive loss of vision which often lead to blindness. Research on retinal microglial cells offers great therapeutic potential in deterring the progression of the condition. This study explored the mechanisms underlying the TREM2-mediated protective function of activated microglial cells during retinal degeneration. A significant upregulation of disease-associated microglia signature genes was observed during photoreceptor degeneration.
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| Overall design |
RNA-Seq on whole-retina samples from rd10 and wild-type mouse retina. Two biological replicates of each.
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| Contributor(s) |
Zhou W, He J, Li J |
| Citation(s) |
39187498 |
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| Submission date |
Jun 25, 2024 |
| Last update date |
Sep 30, 2024 |
| Contact name |
Wenchuan Zhou |
| E-mail(s) |
xixma53@gmail.com
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| Organization name |
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
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| Street address |
No. 1665, Kongjiang Road
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| City |
Shanghai |
| ZIP/Postal code |
200092 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA1128127 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE270758_raw_counts.txt.gz |
558.5 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
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