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Series GSE27033 Query DataSets for GSE27033
Status Public on Mar 30, 2012
Title Genome-wide location analysis of SMRT and NCoR in wild-type and Bcl6 knockout macrophages
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Using ChIP-seq, we reveal the SMRT and NCoR co-repressor cistromes, which each consist of over 30,000 half-shared binding sites. Moreover, we identify Bcl6-bound sub-cistromes for each co-repressor, which are strongly concentrated on NF-κB-driven inflammatory and tissue remodeling genes. These results reveal a critical role for Bcl6 and its corepressors SMRT and NCoR in the prevention of atherosclerosis and chronic inflammation.
Overall design Identification of SMRT and NCoR binding sites in wild-type and Bcl6 knockout primary bone-marrow derived macrophages
Contributor(s) Yu RT, Barish GD, Evans RM
Citation(s) 22465074
Submission date Feb 02, 2011
Last update date May 15, 2019
Contact name Ruth T Yu
Organization name Salk Institute
Department Gene Expression Lab
Lab Ronald Evans
Street address 10010 N Torrey Pines Rd
City La Jolla
State/province CA
ZIP/Postal code 92037
Country USA
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (4)
GSM665925 WT macrophage_SMRT_ChIPSeq
GSM665926 WT macrophage_NCoR_ChIPSeq
GSM665927 Bcl6 KO macrophage_SMRT_ChIPSeq
This SubSeries is part of SuperSeries:
GSE27060 A Bcl6-Smrt/Ncor repression program controls atherosclerosis
SRA SRP005606
BioProject PRJNA141929

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE27033_RAW.tar 2.5 Gb (http)(custom) TAR (of BEDGRAPH, TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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