|
| Status |
Public on Mar 30, 2012 |
| Title |
Genome-wide location analysis of SMRT and NCoR in wild-type and Bcl6 knockout macrophages |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Using ChIP-seq, we reveal the SMRT and NCoR co-repressor cistromes, which each consist of over 30,000 half-shared binding sites. Moreover, we identify Bcl6-bound sub-cistromes for each co-repressor, which are strongly concentrated on NF-κB-driven inflammatory and tissue remodeling genes. These results reveal a critical role for Bcl6 and its corepressors SMRT and NCoR in the prevention of atherosclerosis and chronic inflammation.
|
| |
|
| Overall design |
Identification of SMRT and NCoR binding sites in wild-type and Bcl6 knockout primary bone-marrow derived macrophages
|
| |
|
| Contributor(s) |
Yu RT, Barish GD, Evans RM |
| Citation(s) |
22465074 |
| |
| Submission date |
Feb 02, 2011 |
| Last update date |
May 15, 2019 |
| Contact name |
Ruth T Yu |
| Organization name |
Salk Institute
|
| Department |
Gene Expression Lab
|
| Lab |
Ronald Evans
|
| Street address |
10010 N Torrey Pines Rd
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92037 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
|
| Samples (4)
|
|
| This SubSeries is part of SuperSeries: |
| GSE27060 |
A Bcl6-Smrt/Ncor repression program controls atherosclerosis |
|
| Relations |
| SRA |
SRP005606 |
| BioProject |
PRJNA141929 |
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