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Series GSE269775 Query DataSets for GSE269775
Status Public on Jul 26, 2024
Title Effect of rasagiline on the serum exosome miRNA transcriptome of Parkinson's disease patients (2020)
Organism Homo sapiens
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary Background: Parkinson's disease (PD), a neurodegenerative disease characterised by bradykinesia, rest tremor and rigidit, affects approximately 6.1 million people worldwide. Although its aetiology was attributed to accumulation of misfolded alpha-synuclein species and subsequent loss of dopaminergic neurons in the substantia nigra, recently, systemic factors contributing to its initiation and progression have gained increasing recognition. Specifically, exosomes, a kind of extracellular vesicles in the size range of ∼30 to ∼200 nm, have been highlighted as crucial mediators in orchestrating the intricate intercellular communication in PD. Among its cargos, miRNAs, with its ability to promote target mRNA degradation and inihibit translation, have been identiifed as promising biomarkers and therpaeutic targets. Nonetheless, the effect of anti-parkinsonism medication on the serum exosome miRNA profiles of PD patients remain lagrely unexplored. Objective: To examine the effects of rasagiline, a potentially neuroprotective monoamine oxidase B inihibitor, on the serum exosome miRNA profile of PD patients.
 
Overall design To investigate the effect of rasagilne on the serum exosome miRNA profiles of PD patients, we established four independent cohorts. Two cohorts included PD patients and healthy controls, while the others recorded data from PD patients before and after one year of rasagililne treatment.
 
Contributor(s) Yu Z, Saiki S, Hattori N
Citation(s) 39406833
Submission date Jun 13, 2024
Last update date Oct 17, 2024
Contact name Zhiyang Yu
E-mail(s) yu.np@juntendo.ac.jp
Organization name Juntendo University
Department Department of Neurology
Lab Nobutaka Hattori
Street address Hongo 2-1-1
City Bunkyo
State/province Tokyo to
ZIP/Postal code 1138421
Country Japan
 
Platforms (1)
GPL17301 Ion Torrent PGM (Homo sapiens)
Samples (100)
GSM8326771 Serum exosome miRNA, PD, 2020, 01
GSM8326772 Serum exosome miRNA, PD, 2020, 02
GSM8326773 Serum exosome miRNA, PD, 2020, 03
This SubSeries is part of SuperSeries:
GSE269781 Comprehensive data for studying serum exosome microRNA transcriptome in Parkinson's disease patients
Relations
BioProject PRJNA1123679

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Supplementary file Size Download File type/resource
GSE269775_2020_CountMatrix.xlsx 16.4 Mb (ftp)(http) XLSX
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