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Series GSE267757 Query DataSets for GSE267757
Status Public on May 18, 2024
Title AP-1 regulates heterogeneous cellular dormancy in TNBC
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Slow-cycling cells (SCCs) are a heterogeneous subpopulation of tumor cells. They pre-exist in tumor tissues and evade killing by chemotherapeutics that target mitosis due to their dormant nature. We here utilized varieties of fluorescent dyes or proteins (Claret, H2BeGFP, and Violet) retaining method to label and isolate SCCs, and RNA-seq was performed to understand the gene expression characteristics of subpopulations of SCCs.
Overall design Here we reported that SCCs subgroups share similar gene expression profiles. Up-regulations of AP-1 subunits regulate triple negative breast cancer (TNBC) dormancy by up-regulating the expression of CDKN1A and GADD45 family as transcription factors.
Contributor(s) Dong Y, Tang DG
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Submission date May 17, 2024
Last update date May 18, 2024
Contact name Yang Dong
Phone 19542707574
Organization name Tongji University
Street address Shanghai
City Shanghai
State/province 上海
ZIP/Postal code 200120
Country China
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (4)
GSM8275212 MDA-MB-231 cells, Bulk
GSM8275213 MDA-MB-231 cells, Claret+ SCCs
GSM8275214 MDA-MB-231 cells, H2B-eGFP+ SCCs
BioProject PRJNA1112801

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE267757_gene_count.txt.gz 2.2 Mb (ftp)(http) TXT
GSE267757_gene_fpkm.txt.gz 2.6 Mb (ftp)(http) TXT
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