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| Status |
Public on Jul 08, 2024 |
| Title |
Targeting adenocarcinoma and enzalutamide-resistant prostate cancer using the novel anti-androgen inhibitor ADA-308 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Prostate cancer is a leading cause of cancer-related death among men globally. It often develops resistance to standard androgen deprivation therapy and androgen receptor (AR) pathway inhibitors such as enzalutamide. This resistance highlights the urgent need for novel therapeutic strategies. ADA-308 emerges as a promising candidate, demonstrating potent inhibition of both AR-sensitive adenocarcinoma as well as enzalutamide-resistant prostate cancer cell lines. Our studies reveal that ADA-308 effectively blocks AR activity, including nuclear localization, and inhibits cell proliferation in vitro. Furthermore, ADA-308 demonstrates remarkable efficacy in vivo, showcasing a robust antitumor response in enzalutamide-resistant models. These findings establish ADA-308’s role as a potent AR inhibitor that overcomes resistance to AR-targeted therapies and highlight its potential as a novel therapeutic approach in advanced prostate cancer management.
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| Overall design |
LNCaP cell lines were cultured in RPMI-1640 media plus 5% FBS treated with10µmol/L enzalutamide or ADA-308 for 72 hours. Cells were collected for RNA sequencing.
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| Contributor(s) |
Nouruzi S, Johnson F, Kumar S, Koistinaho M, Muona A, Zoubeidi A |
| Citation(s) |
39129317 |
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| Submission date |
May 13, 2024 |
| Last update date |
Sep 27, 2024 |
| Contact name |
Amina Zoubeidi |
| E-mail(s) |
azoubeidi@prostatecentre.com
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| Organization name |
Vancouver Prostate Centre
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| Street address |
2660 Oak Street
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| City |
Vancouver |
| State/province |
BC |
| ZIP/Postal code |
V6H 3Z6 |
| Country |
Canada |
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| Platforms (1) |
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| Samples (5)
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| Relations |
| BioProject |
PRJNA1111024 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE267309_LNCaP_ADA-308_countMatrix.txt.gz |
335.9 Kb |
(ftp)(http) |
TXT |
| GSE267309_LNCaP_ENZ_countMatrix.txt.gz |
335.8 Kb |
(ftp)(http) |
TXT |
| GSE267309_RAW.tar |
290.0 Kb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
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