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Series GSE26729 Query DataSets for GSE26729
Status Public on Apr 30, 2011
Title The Nucleosome Map of the Mammalian Liver
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We report the genome-wide map of nucleosome positions in the mouse liver, with emphasis on transcriptional start sites, CpG islands, Foxa2 binding sites, and their correlation with gene expression. Despite the heterogeneity of liver tissue, we could clearly discern the nucleosome pattern of the predominant liver cell, the hepatocyte. By analyzing nucleosome occupancy and the distributions of heterochromatin protein 1 (Hp1), CBP, and p300 in Foxa1/2-deficient livers we find, surprisingly, that the maintenance of nucleosome position and chromatin structure surrounding Foxa2 binding sites is independent of Foxa1/2.
Overall design Examination of nucleosome map and Foxa2 binding in the mouse liver.
Contributor(s) Li Z, Kaestner KK
Citation(s) 21623366
Submission date Jan 19, 2011
Last update date May 15, 2019
Contact name Jonathan Schug
Phone 215 898 0773
Organization name University of Pennsylvania
Department School of Medicine
Lab Next-Generation Sequencing Core
Street address 12-156 Smilow Ctr Trans Research
City Philadelphia
State/province Pennsylvania
ZIP/Postal code 19104-5160
Country USA
Platforms (1)
GPL9185 Illumina Genome Analyzer (Mus musculus)
Samples (9)
GSM717558 Nucleosomal DNA_Mnase-Seq
GSM717562 FoxA2 Liver4
GSM717563 FoxA2 Liver5
SRA SRP006582
BioProject PRJNA136145

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Supplementary file Size Download File type/resource
GSE26729_RAW.tar 3.0 Gb (http)(custom) TAR (of BED, TAR)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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