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| Status |
Public on Jun 14, 2024 |
| Title |
Gut-derived memory γδ T17 cells exacerbate sepsis-induced acute lung injury [scRNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Sepsis, a worldwide health crisis, is notorious for its high mortality rate, often attributed to the development of acute lung injury. The direct migration of intestinal immune cells to the lung as a mediator of acute lung injury remains unclear. Our study unveiled a process where cecal ligation and puncture-induced sepsis prompted a migration of γδT cells from the small intestine to the lung, subsequently triggering an overwhelming inflammatory response dominated by IL-17A.
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| Overall design |
CD45+ immune cells from the small intestine tissue of septic and sham-operated C57 mice were isolated Fluorescence-activated cell sorting (FACS) and performed to scRNA seq
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| Citation(s) |
39112475 |
| |
| Submission date |
May 02, 2024 |
| Last update date |
Sep 05, 2024 |
| Contact name |
Mengyuan Wang |
| E-mail(s) |
wmy9058@126.com
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| Phone |
15527199058
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| Organization name |
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
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| Department |
Department of Critical Care Medicine
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| Street address |
NO.1277 JieFang Avenue
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| City |
Wuhan |
| State/province |
Hubei |
| ZIP/Postal code |
430022 |
| Country |
China |
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| Platforms (1) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA1107338 |
