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Series GSE266492 Query DataSets for GSE266492
Status Public on Jun 14, 2024
Title Gut-derived memory γδ T17 cells exacerbate sepsis-induced acute lung injury [ChIP-seq]
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Sepsis, a worldwide health crisis, is notorious for its high mortality rate, often attributed to the development of acute lung injury. The direct migration of intestinal immune cells to the lung as a mediator of acute lung injury remains unclear. Our study unveiled a process where cecal ligation and puncture-induced sepsis prompted a migration of γδT cells from the small intestine to the lung, subsequently triggering an overwhelming inflammatory response dominated by IL-17A.
 
Overall design chromatin immunoprecipitation sequencing (ChIP-seq) experiments targeting Lef1 in MH-S alveolar macrophages to investigate the potential specific binding between Lef1 and CCL1
 
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Submission date May 02, 2024
Last update date Jun 14, 2024
Contact name Mengyuan Wang
E-mail(s) wmy9058@126.com
Phone 15527199058
Organization name Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Department Department of Critical Care Medicine
Street address NO.1277 JieFang Avenue
City Wuhan
State/province Hubei
ZIP/Postal code 430022
Country China
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (2)
GSM8248138 MH-S, ChIP
GSM8248139 MH-S, input
Relations
BioProject PRJNA1107339

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Supplementary file Size Download File type/resource
GSE266492_RAW.tar 207.6 Mb (http)(custom) TAR (of BW, NARROWPEAK)
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Raw data are available in SRA

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