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Series GSE266492 Query DataSets for GSE266492
Status Public on Jun 14, 2024
Title Gut-derived memory γδ T17 cells exacerbate sepsis-induced acute lung injury [ChIP-seq]
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Sepsis, a worldwide health crisis, is notorious for its high mortality rate, often attributed to the development of acute lung injury. The direct migration of intestinal immune cells to the lung as a mediator of acute lung injury remains unclear. Our study unveiled a process where cecal ligation and puncture-induced sepsis prompted a migration of γδT cells from the small intestine to the lung, subsequently triggering an overwhelming inflammatory response dominated by IL-17A.
Overall design chromatin immunoprecipitation sequencing (ChIP-seq) experiments targeting Lef1 in MH-S alveolar macrophages to investigate the potential specific binding between Lef1 and CCL1
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Submission date May 02, 2024
Last update date Jun 14, 2024
Contact name Mengyuan Wang
Phone 15527199058
Organization name Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Department Department of Critical Care Medicine
Street address NO.1277 JieFang Avenue
City Wuhan
State/province Hubei
ZIP/Postal code 430022
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (2)
GSM8248138 MH-S, ChIP
GSM8248139 MH-S, input
BioProject PRJNA1107339

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Supplementary file Size Download File type/resource
GSE266492_RAW.tar 207.6 Mb (http)(custom) TAR (of BW, NARROWPEAK)
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Raw data are available in SRA

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