|
| Status |
Public on Jun 14, 2024 |
| Title |
Gut-derived memory γδ T17 cells exacerbate sepsis-induced acute lung injury [ChIP-seq] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Sepsis, a worldwide health crisis, is notorious for its high mortality rate, often attributed to the development of acute lung injury. The direct migration of intestinal immune cells to the lung as a mediator of acute lung injury remains unclear. Our study unveiled a process where cecal ligation and puncture-induced sepsis prompted a migration of γδT cells from the small intestine to the lung, subsequently triggering an overwhelming inflammatory response dominated by IL-17A.
|
| |
|
| Overall design |
chromatin immunoprecipitation sequencing (ChIP-seq) experiments targeting Lef1 in MH-S alveolar macrophages to investigate the potential specific binding between Lef1 and CCL1
|
| |
|
| Citation(s) |
39112475 |
| |
| Submission date |
May 02, 2024 |
| Last update date |
Sep 05, 2024 |
| Contact name |
Mengyuan Wang |
| E-mail(s) |
wmy9058@126.com
|
| Phone |
15527199058
|
| Organization name |
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
|
| Department |
Department of Critical Care Medicine
|
| Street address |
NO.1277 JieFang Avenue
|
| City |
Wuhan |
| State/province |
Hubei |
| ZIP/Postal code |
430022 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (2) |
|
| Relations |
| BioProject |
PRJNA1107339 |
