 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Sep 13, 2024 |
| Title |
Fully defined NGN2 neuron protocol reveals diverse signatures of neuronal maturation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
This bulk RNAseq dataset is part of a dataset described in the manuscript titled "Fully defined NGN2 neuron protocol reveals diverse signatures of neuronal maturation". This dataset includes NPC derived neurons using a wild type iPSC line, and was used to validate a MS-117 maturation score which attempt to establish a socre system to assess neuronal maturation with iPSCs derived neurons.
|
| |
|
| Overall design |
Three technical replicates were included, and cells were profiled at the NPC stage, as well as cultures undergo neuronal differentiation and maturation at 4 weeks, weeks and 12 weeks upon the induction of terminal differentiation.
|
| Web link |
http://10.1016/j.crmeth.2024.100858
|
| |
|
| Contributor(s) |
Shan X, Zhang Y |
| Citation(s) |
39255791 |
| |
| Submission date |
May 01, 2024 |
| Last update date |
Sep 13, 2024 |
| Contact name |
Ai Zhang |
| E-mail(s) |
zhanga59@gene.com
|
| Phone |
8585249407
|
| Organization name |
Genentech
|
| Department |
Neuroscience
|
| Street address |
1 DNA way
|
| City |
South San Francisco |
| State/province |
California |
| ZIP/Postal code |
94080 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (12)
|
| GSM8245621 |
iPSCs derived neurons, week 4, rep1 |
| GSM8245622 |
iPSCs derived neurons, week 4, rep2 |
| GSM8245623 |
iPSCs derived neurons, week 4, rep3 |
| GSM8245624 |
iPSCs derived neurons, week 8, rep1 |
| GSM8245625 |
iPSCs derived neurons, week 8, rep2 |
| GSM8245626 |
iPSCs derived neurons, week 8, rep3 |
| GSM8245627 |
iPSCs derived neurons, week 12, rep1 |
| GSM8245628 |
iPSCs derived neurons, week 12, rep2 |
| GSM8245629 |
iPSCs derived neurons, week 12, rep3 |
|
| Relations |
| BioProject |
PRJNA1106827 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE266359_raw_counts.csv.gz |
719.3 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
|
|
|
|
 |
Less...
More...