|
| Status |
Public on May 08, 2024 |
| Title |
FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy [human_FOXO1_TCF7_OE_RNAseq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Investigating the transcriptional profile of human FOXO1 or TCF7 overexpressing α-lewisY CAR T cells
|
| |
|
| Overall design |
Human anti-Lewis Y CAR T cells overexpressing mCherry (control), FOXO1 or TCF7 were generated from healthy donor peripheral blood mononuclear cells (PBMC). Control, FOXO1 or TCF7 overexpressing CD8+ CAR T cells were assessed by RNA-Sequencing
|
| |
|
| Contributor(s) |
Beavis P, Darcy P, Sek K, Munoz I |
| Citation(s) |
38600376 |
| |
| Submission date |
Apr 03, 2024 |
| Last update date |
May 08, 2024 |
| Contact name |
Kevin C sek |
| E-mail(s) |
kevin.sek@petermac.org
|
| Phone |
0432960331
|
| Organization name |
Peter MacCallum Cancer Centre
|
| Department |
Cancer Immunology
|
| Lab |
Beavis Lab
|
| Street address |
305 Grattan Street
|
| City |
Melbourne |
| State/province |
VIC |
| ZIP/Postal code |
3000 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (9)
|
|
| This SubSeries is part of SuperSeries: |
| GSE225527 |
Overexpression of FOXO1 enhances CAR T cell polyfunctionality, metabolic fitness and efficacy against solid tumors |
|
| Relations |
| BioProject |
PRJNA1095997 |
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