|
| Status |
Public on Jun 24, 2024 |
| Title |
Interuption of Klf5 acetylaiton at K358 affects tumor microenvironment in Pten deficient mouse prostates |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
PTEN deficiency induces KLF5 acetylation; and the interruption of KLF5 acetylation orchestrates intricate interactions between cancer cells and CAFs that enhance FGFR1 signaling and promote tumor growth. Deacetylated KLF5 promotes tumor cells to secrete TNF, which stimulates inflammatory CAFs to release FGF9. Single-cell transcriptomic analysis reveals an enhanced FGF signaling from fibroblasts to cancer cells after the interruption of Klf5 acetylation.
|
| |
|
| Overall design |
The mouse prostates of 16-week-old PBCre;Pten-/-;Klf5KR/KR (KR) and PBCre;Pten-/-;Klf5+/+ (WT) were dissected and minced for scRNA-seq
|
| Web link |
https://pubmed.ncbi.nlm.nih.gov/38781024/
|
| |
|
| Contributor(s) |
Zhang B, Liu M, Mai F, Ding W, Dong J |
| Citation(s) |
38781024 |
| BioProject |
PRJNA1094424 |
| |
| Submission date |
Mar 31, 2024 |
| Last update date |
Jun 25, 2024 |
| Contact name |
Jin-Tang Dong |
| E-mail(s) |
dongjt@sustech.edu.cn
|
| Organization name |
Southern University of Science and Technology
|
| Department |
Human Cell Biology and Genetics
|
| Street address |
1088 Xueyuan Blvd
|
| City |
Shenzhen |
| State/province |
Guangdong |
| ZIP/Postal code |
518055 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (4)
|
|
Less...
More...