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Series GSE26173 Query DataSets for GSE26173
Status Public on Jan 31, 2011
Title Affymetrix SNP6.0 data for human induced pluripotent stem cells (hiPSCs), human Fibroblasts, and human embryonic stem cells (hESCs)
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
Summary In this study, copy number variations of hiPSCs were compared to their parental fibroblast lines and hESCs to assess the level of DNA damage incurred due to the process of reprogramming of somatic cells. Higher levels of copy number changes were observed in hiPSCs (especially in early passage hiPSCs) compared to the other cell types.
Overall design Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from in vitro cultured cells.
Copy number analysis of Affymetrix SNP 6.0 arrays was performed for 35 hiPSC samples, 2 hESC samples, and 5 fibroblast samples. Other hESC and the reference Hapmap sample CEL files were obtained from Narva et al. 2010, Nat. Biotech., GEO accession code GSE15097 (see readme file below for details).
Contributor(s) Nagy A, Hussein S
Citation(s) 21368824
Submission date Dec 19, 2010
Last update date Nov 27, 2018
Contact name Samer Hussein
Organization name SLRI-Mount Sinai Hosp.
Street address 25 Orde St.
City Toronto
ZIP/Postal code M5T 3H7
Country Canada
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (42)
GSM642743 hESC line CA2, passage 19
GSM642744 hESC line CA1, passage 20
GSM642745 hiPSC line FiPS8-3, passage 4
BioProject PRJNA135255

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE26173_RAW.tar 2.6 Gb (http)(custom) TAR (of CEL, CNCHP, TXT)
GSE26173_readme_HapMapReference.txt 1.9 Kb (ftp)(http) TXT
Processed data included within Sample table
Processed data provided as supplementary file

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