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| Status |
Public on Apr 28, 2024 |
| Title |
EHF is an essential regulator of mammary alveolar lineage differentiation and putative suppressor of breast tumorigenesis |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
The Ets homologous factor (Ehf) is highly expressed in the mammary gland in pregnancy and lactation. Mothers with Ehf deletion fail to lactate due to impaired lobuloalveolar development. ATACseq profiling of luminal mammary epithelial cells at late pregnancy (18.5dP) demonstrated that loss of Ehf results in significant chromatin remodelling.
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| Overall design |
ATAC sequencing of luminal mammary epithelial cells (Ter119–CD31−CD45–CD24+CD29Lo) from mice with and without deletion of Ehf at late pregnancy (18.5 days pregnant)
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| Contributor(s) |
Liao Y, Nightingale R, Reehorst C, Vaillant F, Visvader J, Pal B, Mariadason J, Shi W |
| Citation(s) |
38781975 |
| |
| Submission date |
Mar 05, 2024 |
| Last update date |
Jul 28, 2024 |
| Contact name |
Wei Shi |
| E-mail(s) |
Wei.Shi@onjcri.org.au
|
| Organization name |
Olivia Newton John Cancer Research Institute
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| Department |
Bioinformatics and Cancer Genomics
|
| Street address |
Level 5, ONJ Cancer Centre, 145 Studley Rd
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| City |
Heidelberg |
| State/province |
VIC |
| ZIP/Postal code |
3084 |
| Country |
Australia |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA1083897 |
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