|
| Status |
Public on Sep 15, 2011 |
| Title |
BCL6 is required for the initiation and maintenance of chronic myeloid leukemia |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We identified the BCL6 protooncogene as a critical downstream effector of FoxO3A in self-renewal signaling of CML-initiating cells. BCL6 represses Arf and p53 in CML cells and is required for leukemia stem cell maintenance, colony formation and initiation of leukemia in transplant recipients. Importantly, peptide inhibition of BCL6 in human CML cells compromises colony formation and leukemia-initiation in xenotransplanted mouse recipients. These findings identify peptide-inhibition of BCL6 as a novel strategy to eradicate leukemia-initiating cells in CML.
|
| |
|
| Overall design |
Identification of BCL6 binding sites in human CML cell line JURL-MK1
|
| |
|
| Contributor(s) |
Hatzi K, Hurtz C, Müschen M |
| Citation(s) |
21911423 |
| |
| Submission date |
Dec 15, 2010 |
| Last update date |
May 15, 2019 |
| Contact name |
Katerina Hatzi |
| E-mail(s) |
kac2029@med.cornell.edu
|
| Organization name |
WCMC
|
| Department |
Hematology/Oncology
|
| Lab |
Ari Melnick
|
| Street address |
413 E 69th Street, BB-1462
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10021 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
|
| Samples (2) |
|
| Relations |
| SRA |
SRP004887 |
| BioProject |
PRJNA135225 |
