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| Status |
Public on Feb 08, 2011 |
| Title |
Prolyl hydroxylase PHD3 is essential for hypoxic regulation of neutrophilic inflammation in humans and mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Neutrophils were isolated form peripheral blood of wildtype and Phd3 null mice, cultured for 4 hours in hypoxia (3% O2) and micro array analysis performed
The aim of the present study is to identify the mechanism by which phd3 is required for the hypoxia mediated survival of neutrophils
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| Overall design |
Murine peripheral blood neutrophils were isolated from wildtype and phd3 null mice, cultured for 4 hours in hypoxia (3% O2) and micro array analysis performed
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| Contributor(s) |
Walmsley S, Chilvers E, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell D, Milo M, Taylor CT, Johnson RS, Pugh CW, Ratcliffe PJ, Maxwell PH, Carmeliet P, Whyte MK |
| Citation(s) |
21317538 |
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| Submission date |
Dec 11, 2010 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Sarah Ruth Walmsley |
| E-mail(s) |
s.walmsley@sheffield.ac.uk
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| Organization name |
University of Sheffield
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| Street address |
Department of Infection and Immunity, The Medical School, Beech Hill Road
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| City |
Sheffield |
| ZIP/Postal code |
S10 2RX |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA135485 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE26023_RAW.tar |
13.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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