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| Status |
Public on Dec 03, 2010 |
| Title |
Cardiac gene expression profiling of heart failure treatment with the anti-ischemic drug ranolazine |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Heart failure is a leading cause of cardiovascular mortality with limited options for treatment. We analyzed whether the anti-ischemic drug ranolazine could retard the progression of heart failure in an experimental model of heart failure induced by 6 months of chronic pressure overload. The study showed that 2 months of ranolazine treatment improved cardiac function of aortic constricted C57BL/6J (B6) mice with symptoms of heart failure as assessed by echocardiography. The microarray gene expression study of heart tissue from failing hearts relative to ranolazine-treated and healthy control hearts identified heart failure-specific genes that were normalized during treatment with the anti-ischemic drug ranolazine.
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| Overall design |
Microarray gene expression profiling was performed with heart tissue isolated from three study groups: (i) untreated 10 month-old C57BL/6J (B6) mice with heart failure induced by 6 months of abdominal aortic constriction (AAC), (ii) 10 month-old B6 mice with 6 months of AAC and two months of treatment with the anti-ischemic drug ranolazine (200 mg/kg), and (iii) age-matched, untreated, sham-operated B6 control mice.
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| Contributor(s) |
AbdAlla S, Quitterer U |
| Citation(s) |
21711241, 34576047 |
| |
| Submission date |
Dec 01, 2010 |
| Last update date |
Oct 06, 2021 |
| Contact name |
Ursula Quitterer |
| E-mail(s) |
ursula.quitterer@pharma.ethz.ch
|
| Phone |
+41-446329801
|
| Organization name |
ETH Zurich
|
| Department |
Molecular Pharmacology
|
| Street address |
Winterthurerstrasse 190
|
| City |
Zurich |
| ZIP/Postal code |
CH-8057 |
| Country |
Switzerland |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| GSM632869 |
Failing heart-6 months AAC-age 10 months-BSIX-rep1 |
| GSM632870 |
Failing heart-6 months AAC-age 10 months-BSIX-rep2 |
| GSM632871 |
Control heart-sham-age 10 months-BSIX-rep1 |
| GSM632872 |
Control heart-sham-age 10 months-BSIX-rep2 |
| GSM632877 |
Ranolazine-treated heart-6 months of AAC-age 10 months-BSIX-rep1 |
| GSM632878 |
Ranolazine-treated heart-6 months of AAC-age 10 months-BSIX-rep2 |
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| Relations |
| BioProject |
PRJNA134067 |
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