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Series GSE25674 Query DataSets for GSE25674
Status Public on Nov 30, 2010
Title Genomic Profiling of HMGN1 Reveals an Association with Chromatin at Regulatory Regions
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary High mobility group (HMG) proteins interact with other architectural proteins to regulate chromatin structure. We performed genome-wide mapping experiments to examine the distribution of HMGN1 across the human genome. We discovered that HMGN1 proteins are enriched at regulatory regions such as DNase I HS sites, distal transcription factor binding sites and promoters of actively transcribed genes.

YY1, the Yin Yang 1 transcription factor, is a ubiquitous transcription factor that functions either as a transcriptional activator or a repressor, depending on its interacting partner. To test the preferential localization of HMGN1 with active regulatory regions, we examined the association of transcription factor YY1 and HMGN1 in CD4+ T cells.
Overall design Examination of the genomic profile of HMGN1 and the relationship with regulatory elements in CD4+ T cells.
Contributor(s) Cuddapah S, Schones D, Cui K, Roh T, Barski A, Wei G, Rochman M, Bustin M, Zhao K
Citation(s) 21173166
Submission date Nov 29, 2010
Last update date May 15, 2019
Contact name Dustin E Schones
Organization name City of Hope
Street address 1500 E Duarte Rd.
City Duarte
State/province CA
ZIP/Postal code 91010
Country USA
Platforms (1)
GPL10999 Illumina Genome Analyzer IIx (Homo sapiens)
Samples (3)
GSM630809 HMGN1
GSM630810 YY1
GSM630811 IgG
SRA SRP004717
BioProject PRJNA133869

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Supplementary file Size Download File type/resource
GSE25674_RAW.tar 371.6 Mb (http)(custom) TAR (of BED)
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Raw data are available in SRA
Processed data provided as supplementary file

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