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Series GSE25571 Query DataSets for GSE25571
Status Public on Oct 14, 2011
Title Expression analysis of genes located in the minimally deleted regions of 13q14 and 11q22-23 in chronic lymphocytic leukemia – unexpected expression pattern of the RHO GTPase activator ARHGAP20
Organism Homo sapiens
Experiment type Expression profiling by array
Summary In chronic lymphocytic leukemia (CLL), 13q14 and 11q22-23 deletions are found in 2/3 of the cases. 11q22-23 deletions are associated with poor survival, whereas 13q14 deletions as single abnormality are often found in indolent disease forms. The molecular basis for this difference in prognosis is not known.
ARHGAP20 encodes an evolutionarily conserved protein. In the zebra fish (Danio rerio) genome the syntenic regions of human chromosomal bands 13q14 and 11q22-23 are juxtaposed. The similar expression profiles of ARHGAP20 in 13q14 and 11q22-23 deleted CLL cases suggest a molecular connection and an intriguing mechanism of regulation.
 
Overall design Analysis of 154 samples of peripheral blood mononuclear cells (109 HGU-133plus2; 45 HGU-133A; 45 HGU-133B) from adult patients with chronic lymphocytic leukemia (CLL).
 
Contributor(s) Herold T, Jurinovic V, Mulaw M, Seiler T, Dufour A, Schneider S, Kakadia P, Feuring-Buske M, Braess J, Spiekermann K, Mansmann U, Hiddemann W, Buske C, Bohlander S
Citation(s) 21500311
Submission date Nov 23, 2010
Last update date Mar 25, 2019
Contact name Tobias Herold
E-mail(s) tobias.herold@med.uni-muenchen.de
Organization name University Hospital Grosshadern, Ludwig-Maximilians-University (LMU)
Department Department of Internal Medicine III
Street address Marchioninistr. 15
City Munich
ZIP/Postal code 81377
Country Germany
 
Platforms (3)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
GPL97 [HG-U133B] Affymetrix Human Genome U133B Array
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (199)
GSM628273 CLL_Peripheral_Blood_GED001 HG-U133A II
GSM628274 CLL_Peripheral_Blood_GED003 HG-U133A II
GSM628275 CLL_Peripheral_Blood_GED007 HG-U133A II
Relations
BioProject PRJNA133883

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE25571_RAW.tar 1.2 Gb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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