|
| Status |
Public on Nov 24, 2010 |
| Title |
cAMP/PKA signaling balances respiratory activity with mitochondria dependent apoptosis via transcriptional regulation |
| Platform organisms |
Schizosaccharomyces pombe; Saccharomyces cerevisiae |
| Sample organism |
Saccharomyces cerevisiae |
| Experiment type |
Expression profiling by array
|
| Summary |
This data provides evidence that elevation of cAMP levels has a dramatic effect on the transcriptome of yeast cells, with particular emphasis on mitochondrial function and the promotion of ROS production
|
| |
|
| Overall design |
S. cerevisiae cells lacking the high affinity phosphodiesterase PDE2or both PDE2 and the PKA subunit TPK3 were grown for 24h in rich media in the presence of 4mM exogensously added cAMP. 8 samples.
|
| |
|
| Contributor(s) |
Leadsham JE, Gourlay CW |
| Citation(s) |
21108829 |
| Submission date |
Nov 22, 2010 |
| Last update date |
Feb 21, 2017 |
| Contact name |
Campbell William Gourlay |
| E-mail(s) |
C.W.Gourlay@kent.ac.uk
|
| URL |
http://www.kent.ac.uk/bio/gourlay/
|
| Organization name |
University of Kent
|
| Department |
Biosciences
|
| Street address |
Giles Lane
|
| City |
Canterbury |
| State/province |
Kent |
| ZIP/Postal code |
CT2 7NJ |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL2529 |
[Yeast_2] Affymetrix Yeast Genome 2.0 Array |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA134017 |
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