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Series GSE25468 Query DataSets for GSE25468
Status Public on Jan 10, 2011
Title Expression data from Human foreskin fibroblasts (HFFs) infected with Toxoplasma gondii.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Toxoplasma strains have been shown to modulate host cell transcription. We have found a type II Toxoplasma gene, GRA15, which activates the nuclear translocation of the NF-kappaB p65 transcription factor.
We used microarrays to determine how GRA15II modulates host cell transcription.
Overall design HFFs were infected with type I (RH), type I GRA15II (RH GRA15II), type II (Pru), type II GRA15KO (Pru GRA15KO), type III (cep), or type III GRA15II (cep GRA15II) parasites for 18-24 hours. Some samples were also stimulated with TNF-alpha. Total RNA was isolated and hybridized to Affymetrix GeneChip Human Genome U133A 2.0 arrays.
Contributor(s) Saeij JP, Rosowski EE, Julien L
Citation(s) 21199955
Submission date Nov 18, 2010
Last update date Dec 06, 2018
Contact name Emily E Rosowski
Organization name MIT
Department Biology
Lab Saeij
Street address 77 Massachusetts Ave, 68-258d
City Cambridge
State/province MA
ZIP/Postal code 02139
Country USA
Platforms (2)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (28)
GSM625424 HFF-nostim,noinfection-1
GSM625425 HFF-nostim,noinfection-2
GSM625426 HFF-nostim,noinfection-3
This SubSeries is part of SuperSeries:
GSE25476 Expression data from host cells infected with different strains of Toxoplasma gondii
BioProject PRJNA142585

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE25468_RAW.tar 56.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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