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| Status |
Public on Jun 04, 2024 |
| Title |
RNA sequencing analysis of HG/PA treated podocytes. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Recent studies have shown the crucial role of podocyte injury in the development of diabetic nephropathy. Ubiquitination/deubiquitination is a post-translational modification of proteins, which is widely involved in the occurrence and development of diseases. The purpose of this study was to investigate the role of OTUD5, a deubiquitination enzyme, in podocyte injury and reveal its regulatory mechanism in the pathogenesis of diabetic nephropathy. RNA-seq analysis indicated a significantly increased expression of OTUD5 in HG/PA-stimulated podocytes.
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| Overall design |
we performed RNA sequencing analysis on the podocytes (MPC5) of three control grous and three HG/PA treament grous.
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| Contributor(s) |
Zhao Y, Fan S, Zhu H, Liang G |
| Citation(s) |
38937512 |
| |
| Submission date |
Jan 24, 2024 |
| Last update date |
Jul 31, 2024 |
| Contact name |
guang liang |
| E-mail(s) |
liangguang@wmu.edu.cn
|
| Organization name |
Wenzhou Medical University
|
| Department |
School of Pharmaceutical Sciences
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| Lab |
Chemical Biology Research Center
|
| Street address |
Wenzhou medical university of higher education park chashan town
|
| City |
Wenzhou |
| State/province |
Wenzhou |
| ZIP/Postal code |
325035 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1068460 |
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