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| Status |
Public on Jan 15, 2024 |
| Title |
Venous plexus-associated lymphoid hubs support meningeal humoral immunity |
| Organism |
Mus musculus |
| Experiment type |
Other
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| Summary |
We have identified previously unappreciated dural-associated lymphoid tissue hubs, present in homeostasis, and anatomically poised to acquire local and systemic antigens. These venolymphatic hubs facilitate rapid expansion of antigen specific immune responses and likely help defend the underlying CNS parenchyma against foreign invaders.
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| Overall design |
BCR sequencing of anatomical/immune compartments 1 week or 3 weeks following nasal VSV challenge, or in naïve mice. Sequencing was performed on paired skull base, rostral-rhinal hub, superior saggital sinus dura, skull bone marrow, cervical lymph node and spleen tissues. Anti-LFA1/VLA4 antibodies or isotype control antibodies were administered starting 6 days post infection (6dpi) where indicated.
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| Contributor(s) |
Fitzpatrick Z, Zanluqui NG, Clatworthy MR, McGavern DB |
| Citation(s) |
38509366 |
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| Submission date |
Jan 12, 2024 |
| Last update date |
Apr 15, 2024 |
| Contact name |
Colin YC Lee |
| E-mail(s) |
cl28@sanger.ac.uk
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| Organization name |
Molecular Immunity Unit
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| Lab |
Clatworthy Lab
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| Street address |
Wellcome Genome Campus, Hinxton
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| City |
Cambridge |
| ZIP/Postal code |
CB10 1SA |
| Country |
United Kingdom |
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| Platforms (1) |
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| Samples (91)
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| GSM8014692 |
Naïve, skull base, rep 4 |
| GSM8014693 |
Naïve, skull base, rep 5 |
| GSM8014694 |
Naïve, skull BM, rep 1 |
| GSM8014695 |
Naïve, skull BM, rep 2 |
| GSM8014696 |
Naïve, skull BM, rep 3 |
| GSM8014697 |
Naïve, skull BM, rep 4 |
| GSM8014698 |
Naïve, skull BM, rep 5 |
| GSM8014699 |
Naïve, cLN, rep 1 |
| GSM8014700 |
Naïve, cLN, rep 2 |
| GSM8014701 |
Naïve, cLN, rep 3 |
| GSM8014702 |
Naïve, cLN, rep 4 |
| GSM8014703 |
Naïve, cLN, rep 5 |
| GSM8014704 |
Naïve, hub, rep 1 |
| GSM8014705 |
Naïve, hub, rep 2 |
| GSM8014706 |
Naïve, hub, rep 3 |
| GSM8014707 |
Naïve, hub, rep 4 |
| GSM8014708 |
Naïve, hub, rep 5 |
| GSM8014709 |
Naïve, sinus, rep 1 |
| GSM8014710 |
Naïve, sinus, rep 2 |
| GSM8014711 |
Naïve, sinus, rep 3 |
| GSM8014712 |
Naïve, sinus, rep 4 |
| GSM8014713 |
Naïve, sinus, rep 5 |
| GSM8014714 |
Naïve, spleen, rep 1 |
| GSM8014715 |
Naïve, spleen, rep 2 |
| GSM8014716 |
Naïve, spleen, rep 3 |
| GSM8014717 |
Naïve, spleen, rep 4 |
| GSM8014718 |
Naïve, spleen, rep 5 |
| GSM8014719 |
Week 1 VSV, skull base, rep 1 |
| GSM8014720 |
Week 1 VSV, skull base, rep 2 |
| GSM8014721 |
Week 1 VSV, skull base, rep 3 |
| GSM8014722 |
Week 1 VSV, skull base, rep 5 |
| GSM8014723 |
Week 1 VSV, skull BM, rep 1 |
| GSM8014724 |
Week 1 VSV, skull BM, rep 2 |
| GSM8014725 |
Week 1 VSV, skull BM, rep 3 |
| GSM8014726 |
Week 1 VSV, skull BM, rep 4 |
| GSM8014727 |
Week 1 VSV, skull BM, rep 5 |
| GSM8014728 |
Week 1 VSV, cLN, rep 1 |
| GSM8014729 |
Week 1 VSV, cLN, rep 2 |
| GSM8014730 |
Week 1 VSV, cLN, rep 3 |
| GSM8014731 |
Week 1 VSV, cLN, rep 4 |
| GSM8014732 |
Week 1 VSV, cLN, rep 5 |
| GSM8014733 |
Week 1 VSV, hub, rep 1 |
| GSM8014734 |
Week 1 VSV, hub, rep 4 |
| GSM8014735 |
Week 1 VSV, hub, rep 5 |
| GSM8014736 |
Week 1 VSV, sinus, rep 1 |
| GSM8014737 |
Week 1 VSV, sinus, rep 2 |
| GSM8014738 |
Week 1 VSV, sinus, rep 3 |
| GSM8014739 |
Week 1 VSV, sinus, rep 4 |
| GSM8014740 |
Week 1 VSV, sinus, rep 5 |
| GSM8014741 |
Week 1 VSV, spleen, rep 1 |
| GSM8014742 |
Week 1 VSV, spleen, rep 2 |
| GSM8014743 |
Week 1 VSV, spleen, rep 3 |
| GSM8014744 |
Week 1 VSV, spleen, rep 4 |
| GSM8014745 |
Week 1 VSV, spleen, rep 5 |
| GSM8014746 |
Week 3 VSV, skull base, rep 1 |
| GSM8014747 |
Week 3 VSV, skull base, rep 2 |
| GSM8014748 |
Week 3 VSV, skull base, rep 3 |
| GSM8014749 |
Week 3 VSV, skull base, rep 4 |
| GSM8014750 |
Week 3 VSV, skull base, rep 5 |
| GSM8014751 |
Week 3 VSV, skull BM, rep 1 |
| GSM8014752 |
Week 3 VSV, skull BM, rep 2 |
| GSM8014753 |
Week 3 VSV, skull BM, rep 3 |
| GSM8014754 |
Week 3 VSV, skull BM, rep 4 |
| GSM8014755 |
Week 3 VSV, skull BM, rep 5 |
| GSM8014756 |
Week 3 VSV, cLN, rep 1 |
| GSM8014757 |
Week 3 VSV, cLN, rep 2 |
| GSM8014758 |
Week 3 VSV, cLN, rep 3 |
| GSM8014759 |
Week 3 VSV, cLN, rep 4 |
| GSM8014760 |
Week 3 VSV, cLN, rep 5 |
| GSM8014761 |
Week 3 VSV, hub, rep 1 |
| GSM8014762 |
Week 3 VSV, hub, rep 2 |
| GSM8014763 |
Week 3 VSV, hub, rep 3 |
| GSM8014764 |
Week 3 VSV, hub, rep 4 |
| GSM8014765 |
Week 3 VSV, hub, rep 5 |
| GSM8014766 |
Week 3 VSV, sinus, rep 1 |
| GSM8014767 |
Week 3 VSV, sinus, rep 2 |
| GSM8014768 |
Week 3 VSV, sinus, rep 3 |
| GSM8014769 |
Week 3 VSV, sinus, rep 4 |
| GSM8014770 |
Week 3 VSV, sinus, rep 5 |
| GSM8014771 |
Week 3 VSV, spleen, rep 1 |
| GSM8014772 |
Week 3 VSV, spleen, rep 2 |
| GSM8014773 |
Week 3 VSV, spleen, rep 3 |
| GSM8014774 |
Week 3 VSV, spleen, rep 4 |
| GSM8014775 |
Week 3 VSV, spleen, rep 5 |
| GSM8014776 |
6dpi VSV, hub, expt 2 |
| GSM8014777 |
21dpi VSV, hub, expt 2, isotype |
| GSM8014778 |
21dpi VSV, hub, expt 2, anti-LFA1-VLA4 |
| GSM8014779 |
Naïve, hub, expt 2 |
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| Relations |
| BioProject |
PRJNA1064095 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE253135_RAW.tar |
68.8 Mb |
(http)(custom) |
TAR (of FASTA) |
SRA Run Selector |
| Raw data are available in SRA |
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