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| Status |
Public on May 17, 2024 |
| Title |
Multi-Omics molecular subtyping based on commensal microbiome predicts molecular characteristics and therapeutic response in Triple-Negative Breast Cancer [Spatial Transcriptome seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Other
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| Summary |
We thoroughly analyzed the molecular subtyping of Triple-Negative Breast Cancer and its different manifestations, and located T cells and Tumor cells related to the survival of breast cancer through single cell sequencing and space transcriptome according to our score, and finally investigated their relationship with the therapeutic efficacy, providing a scientific basis for the treatment of triple negative breast cancer.
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| Overall design |
10x Single-cell Transcriptome sequencing were used to obtain the characteristics of 2 TNBC samples , and 10x Spatial Transcriptome sequencing were used to obtain the characteristics of 4 TNBC samples.
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| Contributor(s) |
Qi F, Li J, Gao N, Qin W |
| Citation(s) |
38730464 |
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| Submission date |
Dec 28, 2023 |
| Last update date |
May 18, 2024 |
| Contact name |
Qi Feng |
| E-mail(s) |
qf12486@rjh.com.cn
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| Organization name |
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
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| Department |
Department of Oncology
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| Street address |
No. 197 Ruijin Second Road
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| City |
Shanghai |
| ZIP/Postal code |
200000 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (4)
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| GSM7996201 |
TNBC tissue, replicate 1 [Spatial Transcriptome] |
| GSM7996202 |
TNBC tissue, replicate 2 [Spatial Transcriptome] |
| GSM7996203 |
TNBC tissue, replicate 3 [Spatial Transcriptome] |
| GSM7996204 |
TNBC tissue, replicate 4 [Spatial Transcriptome] |
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| Relations |
| BioProject |
PRJNA1058423 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE252176_RAW.tar |
191.1 Mb |
(http)(custom) |
TAR (of CSV, JPG, JSON, MTX, PNG, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
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