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Series GSE25193 Query DataSets for GSE25193
Status Public on Nov 09, 2010
Title Human fetal penile smooth muscle cells (hfPSCM): Control vs PCB mixtures treatments
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The effects exerted by three mixtures of Polychlorinated Biphenyls (PCB), one featuring dioxin-like (DL) and two featuring non dioxin-like (NDL) congeners, on human fetal corpora cavernosa cells representative of a major male endocrine-sensitive organ, have been evaluated by gene expression profiling. PCB congeners concentrations used were derived from human internal exposure data to explore the impact of the adult body burden on a fetal tissue. Cell exposure were performed for 72h mimicking a chronic exposure.
Overall design Experiment conditions: control, three treatments with PCB-Mix1, PCB-Mix2 or PCB-Mix3. Biological replicates: 3 control replicates, 3 replicates per treatment. Technical replica: 2 (dye swap) per biological replica. Direct comparison design (control vs treated samples) in 12/16 arrays (biological replicates 1 and 2); Loop design in 4/16 arrays (biological replicate 3).
Contributor(s) Tait S
Citation(s) 21334430
Submission date Nov 08, 2010
Last update date Feb 22, 2018
Contact name Sabrina Tait
Organization name Istituto Superiore di Sanità
Department Dpt. Veterinary Public Health and Food Safety
Lab Food And Veterinary Toxicology Unit
Street address Viale Regina Elena 299
City Rome
State/province Italy
ZIP/Postal code 00163
Country Italy
Platforms (1)
GPL4133 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
Samples (16)
GSM618837 hfPSMC_CTRLvsMix1_biolrep1_techrepl1
GSM618838 hfPSMC_CTRLvsMix2_biolrep1_techrepl1
GSM618839 hfPSMC_CTRLvsMix3_biolrep1_techrepl1
BioProject PRJNA134299

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE25193_RAW.tar 250.6 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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