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| Status |
Public on Nov 04, 2010 |
| Title |
Expression data from CD19-positive splenic B cells isolated from 1-month old ID4+/-TCL1-tg and ID4+/+TCL1-tg mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The function of ID4 in CLL development was studied in vivo using TCL1 transgenic mouse model that develop leukemia similar to human CLL. TCL1 mice with ID4 single knockout gene have accelerated CLL progression.
Results from the animal study suggest ID4 as a tumor suppressor gene that might regulate cell proliferation and apoptosis in B lymphocytes.
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| Overall design |
Gene expression in CD19-positive splenic B cells collected from 1-month old ID4+/-TCL1-tg and ID4+/+TCL1-tg mice was compared by microarray, the goal is to find ID4-regulated genes involved in CLL development.
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| |
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| Contributor(s) |
Chen S, Yu L |
| Citation(s) |
21098398 |
| |
| Submission date |
Nov 03, 2010 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Lianbo Yu |
| Organization name |
The Ohio State University
|
| Department |
Center for Biostatistics
|
| Lab |
320 Lincoln Tower
|
| Street address |
1800 Cannon Drive
|
| City |
Columbus |
| State/province |
OH |
| ZIP/Postal code |
43210 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| GSM616662 |
ID4+/-TCL1-tg spleen CD19+ B cells collected from 3 mice 1 |
| GSM616663 |
ID4+/-TCL1-tg spleen CD19+ B cells collected from 3 mice 2 |
| GSM616664 |
ID4+/-TCL1-tg spleen CD19+ B cells collected from 3 mice 3 |
| GSM616665 |
ID4+/+TCL1-tg spleen CD19+ B cells collected from 3 mice 1 |
| GSM616666 |
ID4+/+TCL1-tg spleen CD19+ B cells collected from 3 mice 2 |
| GSM616667 |
ID4+/+TCL1-tg spleen CD19+ B cells collected from 3 mice 3 |
|
| Relations |
| BioProject |
PRJNA134723 |
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