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| Status |
Public on Apr 02, 2024 |
| Title |
Characterisation of TET function in drosophila larval central nervous system |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Enzymes of the Ten Eleven Translocation (TET) family play a key role in the regulation of gene expression in many species by oxidizing 5-methylcytosine (5mC), a prominent epigenetic mark, into 5-hydroxymethylcytosine (5hmC). Yet, TET proteins also have non-canonical modes of action beyond 5mC oxidation, notably in Drosophila, whose genomes is devoid of 5mC. Here, we used a combination of NGS analyses to studied the funciton and mode of action of Tet in the central nervous system of Drosophila larvae.
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| Overall design |
All experiments were performed with biological replicates (duplicates for ChIP-seq and CUT&RUN; quadruplicates for RNA-seq). w1118 (wt)were used as control lines.
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| Contributor(s) |
Waltzer L, Renaud Y, Vandel L, Gilbert G |
| Citation missing |
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| |
| Submission date |
Dec 18, 2023 |
| Last update date |
Apr 02, 2024 |
| Contact name |
yoan renaud |
| E-mail(s) |
yoan.renaud@uca.fr
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| Organization name |
igred
|
| Street address |
place henri dunand
|
| City |
clermont ferrand |
| ZIP/Postal code |
63000 |
| Country |
France |
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| Platforms (1) |
| GPL25244 |
Illumina NovaSeq 6000 (Drosophila melanogaster) |
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| Samples (46)
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| Relations |
| BioProject |
PRJNA1054017 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE250415_GAF_fusion_profil.bw |
15.2 Mb |
(ftp)(http) |
BW |
| GSE250415_H2A_Tet-null_fusion.bw |
16.4 Mb |
(ftp)(http) |
BW |
| GSE250415_H2A_WT_fusion.bw |
16.3 Mb |
(ftp)(http) |
BW |
| GSE250415_H3K27ac_Tet-null_fusion.bw |
15.6 Mb |
(ftp)(http) |
BW |
| GSE250415_H3K27ac_WT_fusion.bw |
15.3 Mb |
(ftp)(http) |
BW |
| GSE250415_H3K27me3_Tet-null_fusion_profil.bw |
15.1 Mb |
(ftp)(http) |
BW |
| GSE250415_H3K27me3_WT_fusion_profil.bw |
15.3 Mb |
(ftp)(http) |
BW |
| GSE250415_H3K4me3_Tet-null_fusion.bw |
18.9 Mb |
(ftp)(http) |
BW |
| GSE250415_H3K4me3_TetCD_fusion.bw |
15.5 Mb |
(ftp)(http) |
BW |
| GSE250415_H3K4me3_WT_for_Tet-null_fusion.bw |
19.1 Mb |
(ftp)(http) |
BW |
| GSE250415_H3K4me3_WT_for_TetCD_fusion.bw |
15.6 Mb |
(ftp)(http) |
BW |
| GSE250415_IgG_fusion.bw |
14.8 Mb |
(ftp)(http) |
BW |
| GSE250415_Input_profil_fusion.bw |
18.2 Mb |
(ftp)(http) |
BW |
| GSE250415_TET-CD_profil.bw |
33.6 Mb |
(ftp)(http) |
BW |
| GSE250415_TET-GFP_profil.bw |
45.4 Mb |
(ftp)(http) |
BW |
| GSE250415_WT_profil_forTetGFP.bw |
45.3 Mb |
(ftp)(http) |
BW |
| GSE250415_WT_profil_for_TetCD.bw |
18.6 Mb |
(ftp)(http) |
BW |
| GSE250415_rpkm_all.txt.gz |
1.3 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
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