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| Status |
Public on Dec 04, 2023 |
| Title |
Pan-cancer analysis of pyrimidine metabolism using pathway-based approach unravels complex signaling pathways connections with a role in chemoresistance |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the effect of DHODH inhibitor, Brequinar (BRQ), in inhibiting the pyrimidine metabolism and its associated signaling pathways, lung cancer cell line (A549) was treated with BRQ for 72 hours and performed gene expression profiling using RNA-seq.
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| Overall design |
Differential gene expression analysis for A549 cells treated with BRQ and control cells at 72 hours in replicates.
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| Contributor(s) |
Ramesh V, Pinna L, Ceppi P |
| Citation missing |
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| Submission date |
Nov 27, 2023 |
| Last update date |
Dec 04, 2023 |
| Contact name |
Paolo Ceppi |
| E-mail(s) |
pceppi@bmb.sdu.dk
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| Organization name |
University of Southern Denmark
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| Department |
Department of Biochemistry and Molecular Biology
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| Street address |
Campusvej 55
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| City |
Odense |
| ZIP/Postal code |
5230 |
| Country |
Denmark |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1045592 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE248686_Raw_Count_Table.txt.gz |
503.9 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
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