Expression profiling by high throughput sequencing
Summary
We conducted a single-center, open-label, Simon two-stage, phase II study of entinostat in combination with the PD1 inhibitor nivolumab in patients with advanced pancreatic ductal adenocarcinoma. Patients received oral entinostat 5 mg once a week. After a 14-day lead-in with entinostat monotherapy, patients concurrently receive entinostat 5 mg orally once a week plus nivolumab 240 mg intravenously until the time of progression or unacceptable toxicities.
Overall design
All patients underwent fresh tumor biopsy (subsequent passes flash frozen, formalin-fixed paraffin-embedded, and preserved in RNAlater) at baseline, after two weeks of entinostat lead-in therapy (C1D1), and on week 6 following entinostat given with nivolumab combination therapy (C2D1). ----------------------------------------- Authors state: This is patient RNAseq data. Here we post only processed data and will submit raw files to dbGap
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