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Series GSE245898 Query DataSets for GSE245898
Status Public on Jun 21, 2024
Title Digital transformation of herbal medicine: Conversion to biological entity data using tonifying herbal medicine-induced transcriptome sequencing_SW1783_batchB
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary This study aimed to identify transcript expression induced by tonifying herbal medicines (THM) and modes of action (MOA) of THM in A549 cell line. For the production of THM-induced transcripts, tonifying herbal medicines water extract (THW) and tonifying herbal medicines ethanol extract (THE) were used.
 
Overall design Comparative gene expression profiling analysis of RNA-seq data for THW (500 ug/mL, 100 ug/mL, and 20 ug/mL, respectively), THE (500 ug/mL, 100 ug/mL, and 20 ug/mL, respectively), positive control (wortmannin, LY294002, and thioridazine 10uM, respectively), and vehicle control (2% DMSO). However, in extracts with IC20 of less than 500ug/mL, the concentration at IC20 and the concentration diluted to 1/5 and 1/25 of the IC20 concentration were used, respectively.
 
Contributor(s) Park M
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Submission date Oct 20, 2023
Last update date Jun 21, 2024
Contact name Musun Park
E-mail(s) bmusun@kiom.re.kr
Organization name Korean Institute of Oriental Medicine
Street address 1672 Yuseong-daero, Yuseong-gu
City Daejeon
ZIP/Postal code 34054
Country South Korea
 
Platforms (1)
GPL30209 MGISEQ-2000RS (Homo sapiens)
Samples (60)
GSM7850564 BatchB_Vehicle(DMSO)_rep1
GSM7850565 BatchB_Vehicle(DMSO)_rep2
GSM7850566 BatchB_Vehicle(DMSO)_rep3
This SubSeries is part of SuperSeries:
GSE245912 Digital transformation of herbal medicine: Conversion to biological entity data using tonifying herbal medicine-induced transcriptome sequencing_Tonifying_SW1783
Relations
BioProject PRJNA1030371

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE245898_RCM_tonifying_SW1783.txt.gz 11.9 Mb (ftp)(http) TXT
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