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| Status |
Public on Dec 02, 2023 |
| Title |
Embryos Assist Each Other’s Morphogenesis: calcium and ATP signaling mechanisms in collective resistance to teratogens (Stage 25) |
| Organism |
Xenopus laevis |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We investigated whether normal embryonic developmental cues are only at the level of cells within the embryo or whether they exist in interactions between embryos. To explore this, we subjected groups of embryos with disruptors of normal development while varying group size. RNA-seq analysis revealed a small set of transcripts specific for teratogen response in large groups but not small ones.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for metamorphosing X. laevis tadpoles exposed to thioridazine. Control and exposed treatments in triplicate.
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| Contributor(s) |
Tung A, Sperry M, Levin M |
| Citation(s) |
38233424 |
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| Submission date |
Oct 19, 2023 |
| Last update date |
Jan 29, 2024 |
| Contact name |
Megan M Sperry |
| Organization name |
Wyss Institute at Harvard University
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| Street address |
3 Blackfan Circle
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115-5713 |
| Country |
USA |
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| Platforms (1) |
| GPL18936 |
Illumina HiSeq 2500 (Xenopus laevis) |
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| Samples (12)
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| GSM7848948 |
thioridazine-treated, small group, sample 1 |
| GSM7848949 |
thioridazine-treated, small group, sample 2 |
| GSM7848950 |
thioridazine-treated, small group, sample 3 |
| GSM7848951 |
thioridazine-treated, large group, sample 1 |
| GSM7848952 |
thioridazine-treated, large group, sample 2 |
| GSM7848953 |
thioridazine-treated, large group, sample 3 |
| GSM7848954 |
control, small group, sample 1 |
| GSM7848955 |
control, small group, sample 2 |
| GSM7848956 |
control, small group, sample 3 |
| GSM7848957 |
control, large group, sample 1 |
| GSM7848958 |
control, large group, sample 2 |
| GSM7848959 |
control, large group, sample 3 |
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| This SubSeries is part of SuperSeries: |
| GSE245782 |
Embryos Assist Each Other’s Morphogenesis: calcium and ATP signaling mechanisms in collective resistance to teratogens |
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| Relations |
| BioProject |
PRJNA1029975 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE245780_logCPM_for_plotting.xlsx |
3.1 Mb |
(ftp)(http) |
XLSX |
| GSE245780_rsem_gene_counts.tsv.gz |
890.2 Kb |
(ftp)(http) |
TSV |
SRA Run Selector |
| Raw data are available in SRA |
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