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| Status |
Public on Jul 31, 2024 |
| Title |
AS01-adjuvanted vaccine promotes functional and epigenetic modifications in monocytes [scATAC-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
HBS/AS01 adjuvanted vaccine induces changes in the chromatin structure in monocyte population impacting their gene expression, an effect that lasts until 6 months post vaccination
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| Overall design |
frozen PBMCS isolated at D32, D44, D60, D180 post dose 2 after HBS/AS01 vaccination were depleted from CD3+ cells and processed via single cell ATACseq
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Submitter states that missing raw files are due to patient privacy concerns.
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| Contributor(s) |
Bechtold V, Essaghir A, Scaillet A, Tilman S, Bozzetti B |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Oct 06, 2023 |
| Last update date |
Jul 31, 2024 |
| Contact name |
Viviane Jeanne Bechtold |
| E-mail(s) |
viviane.x.bechtold@gsk.com
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| Organization name |
GSK
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| Department |
Molecular Biology
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| Lab |
Vaccinomics
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| Street address |
rue de l'Institut 89
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| City |
Rixensart |
| State/province |
Brabant Wallon |
| ZIP/Postal code |
1330 |
| Country |
Belgium |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (31)
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| GSM7829741 |
CD3+ depleted, epigenetic: ATAC, D0, S3 |
| GSM7829742 |
CD3+ depleted, epigenetic: ATAC, D180, S3 |
| GSM7829743 |
CD3+ depleted, epigenetic: ATAC, D32, S3 |
| GSM7829744 |
CD3+ depleted, epigenetic: ATAC, D44, S3 |
| GSM7829745 |
CD3+ depleted, epigenetic: ATAC, D0, S7 |
| GSM7829746 |
CD3+ depleted, epigenetic: ATAC, D180, S7 |
| GSM7829747 |
CD3+ depleted, epigenetic: ATAC, D32, S7 |
| GSM7829748 |
CD3+ depleted, epigenetic: ATAC, D44, S7 |
| GSM7829749 |
CD3+ depleted, epigenetic: ATAC, D0, S8 |
| GSM7829750 |
CD3+ depleted, epigenetic: ATAC, D180, S8 |
| GSM7829751 |
CD3+ depleted, epigenetic: ATAC, D32, S8 |
| GSM7829752 |
CD3+ depleted, epigenetic: ATAC, D44, S8 |
| GSM7829753 |
CD3+ depleted, epigenetic: ATAC, D60, S8 |
| GSM7829754 |
CD3+ depleted, epigenetic: ATAC, D0, S9 |
| GSM7829755 |
CD3+ depleted, epigenetic: ATAC, D180, S9 |
| GSM7829756 |
CD3+ depleted, epigenetic: ATAC, D32, S9 |
| GSM7829757 |
CD3+ depleted, epigenetic: ATAC, D44, S9 |
| GSM7829758 |
CD3+ depleted, epigenetic: ATAC, D0, S12 |
| GSM7829759 |
CD3+ depleted, epigenetic: ATAC, D180, S12 |
| GSM7829760 |
CD3+ depleted, epigenetic: ATAC, D32, S12 |
| GSM7829761 |
CD3+ depleted, epigenetic: ATAC, D44, S12 |
| GSM7829762 |
CD3+ depleted, epigenetic: ATAC, D60, S12 |
| GSM7829763 |
CD3+ depleted, epigenetic: ATAC, D0, S14 |
| GSM7829764 |
CD3+ depleted, epigenetic: ATAC, D180, S14 |
| GSM7829765 |
CD3+ depleted, epigenetic: ATAC, D32, S14 |
| GSM7829766 |
CD3+ depleted, epigenetic: ATAC, D44, S14 |
| GSM7829767 |
CD3+ depleted, epigenetic: ATAC, D60, S14 |
| GSM7829768 |
CD3+ depleted, epigenetic: ATAC, D0, S19 |
| GSM7829769 |
CD3+ depleted, epigenetic: ATAC, D180, S19 |
| GSM7829770 |
CD3+ depleted, epigenetic: ATAC, D32, S19 |
| GSM7829771 |
CD3+ depleted, epigenetic: ATAC, D44, S19 |
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| This SubSeries is part of SuperSeries: |
| GSE244795 |
AS01-adjuvanted vaccine promotes functional and epigenetic modifications in monocytes |
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| Relations |
| BioProject |
PRJNA1024904 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE244792_RAW.tar |
1.7 Gb |
(http)(custom) |
TAR (of H5) |
| Raw data are available in SRA |
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