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Series GSE24427 Query DataSets for GSE24427
Status Public on Sep 29, 2010
Title Expression data of multiple sclerosis patients receiving subcutaneous Interferon-beta-1b therapy [U133 A and B]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The purpose of this study was to characterize the transcriptional effects induced by subcutaneous IFN-beta-1b treatment (Betaferon, 250 µg every other day) in patients with relapsing-remitting form of multiple sclerosis (MS).
By using Affymetrix DNA microarrays, we obtained genome-wide expression profiles of peripheral blood mononuclear cells from 25 MS patients within the first two years of IFN-beta administration.
 
Overall design EDTA blood samples were drawn from all patients immediately before first, second, month 1, 12, and 24 IFN-beta injection.
Total RNA of Ficoll-isolated peripheral blood mononuclear cells from each sample was extracted, labeled and hybridized to Affymetrix Human Genome U133 A and B arrays to quantify the mRNA levels.
 
Contributor(s) Goertsches RH, Hecker M, Koczan D, Zettl UK
Citation(s) 20136355, 22727118, 22216338
Submission date Sep 29, 2010
Last update date Sep 24, 2019
Contact name Robert Goertsches
E-mail(s) robert.goertsches@med.uni-rostock.de
Organization name University
Department Neurology
Lab Neuroimmunology
Street address Gehlsheimer Strasse 20
City Rostock
ZIP/Postal code 18047
Country Germany
 
Platforms (2)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
GPL97 [HG-U133B] Affymetrix Human Genome U133B Array
Samples (250)
GSM601747 Patient 1, before first IFN-beta injection_chipA
GSM601748 Patient 1, before second IFN-beta injection_chipA
GSM601749 Patient 1, before month1 IFN-beta injection_chipA
Relations
BioProject PRJNA132617

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE24427_RAW.tar 887.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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