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| Status |
Public on Aug 19, 2024 |
| Title |
Dietary folate and cofactors accelerate age-dependent p16 epimutation to promote intestinal tumorigenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We use a mouse model of age-dependent p16 epimutation, in which the p16 gene activity is directly controlled by promoter DNA methylation. We show p16 epimutation is modulated by folate and cofactors in dietary supplementation, which leads to increased colon cancer risk. Importantly, our findings provide functional evidence concerning the safety of folate fortification in the general population.
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| Overall design |
As a control, we analyzed cells from adjacent normal colonic mucosa.
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| Contributor(s) |
Yang L, Shen L |
| Citation(s) |
38259096 |
| |
| Submission date |
Sep 21, 2023 |
| Last update date |
Aug 20, 2024 |
| Contact name |
Lanlan Shen |
| E-mail(s) |
lanlanshenlab@gmail.com
|
| Organization name |
Baylor College of Medicine
|
| Department |
Pediatrics
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| Lab |
Shen
|
| Street address |
1100 Bates Ave
|
| City |
Houston |
| State/province |
Texas |
| ZIP/Postal code |
77030 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (13)
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| Relations |
| BioProject |
PRJNA1019771 |
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