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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Sep 24, 2024 |
| Title |
Targeting Lysine Demethylase 5 (KDM5) in Mantle Cell Lymphoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Loss of function mutations in the histone methyltransferase KMT2D are common in lymphomas but difficult to target. We reported targeting KDM5 restores epigenetic balance in germinal centre (GC) lymphomas. Here, we show the KDM5 family are over-expressed in mantle cell lymphoma (MCL). GS716054, a pro-drug, increases H3K4 trimethylation (H3K4me3) and kills MCL cells including TP53 mutated cells via suppression of the MYC pathway. It can overcome ibrutinib resistance and synergises with ibrutinib. These data suggest a possible role for KDM5-inhibitors in advanced MCL.
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| Overall design |
3 celllines were treated with either control (DMSO) or KDM5 inhibitor (GS716054) and RNAseq was performed after 24 or 72 hours post treatment.
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| Web link |
https://www.nature.com/articles/s41408-024-00999-8
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| Contributor(s) |
Xu D, Bewicke-Copley F, Close K, Okosun J, Gale RP, Apperley J, Weinstock D, Fitzgibbon J |
| Citation missing |
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| Submission date |
Sep 18, 2023 |
| Last update date |
Sep 25, 2024 |
| Contact name |
Findlay Bewicke-Copley |
| E-mail(s) |
f.copley@qmul.ac.uk
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| Organization name |
Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London
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| Street address |
John Vane Science Centre, Barts Cancer Institute
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| City |
London |
| ZIP/Postal code |
EC1M 6BQ |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (36)
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| GSM7784959 |
JEKO, GS716054 , 24hrs, r1 |
| GSM7784960 |
JEKO, GS716054 , 24hrs, r2 |
| GSM7784961 |
JEKO, GS716054 , 24hrs, r3 |
| GSM7784962 |
JEKO, DMSO, 72hrs, r1 |
| GSM7784963 |
JEKO, DMSO, 72hrs, r2 |
| GSM7784964 |
JEKO, DMSO, 72hrs, r3 |
| GSM7784965 |
JEKO, GS716054 , 72hrs, r1 |
| GSM7784966 |
JEKO, GS716054 , 72hrs, r2 |
| GSM7784967 |
JEKO, GS716054 , 72hrs, r3 |
| GSM7784968 |
MINO, DMSO, 24hrs, r1 |
| GSM7784969 |
MINO, DMSO, 24hrs, r2 |
| GSM7784970 |
MINO, DMSO, 24hrs, r3 |
| GSM7784971 |
MINO, GS716054 , 24hrs, r1 |
| GSM7784972 |
MINO, GS716054 , 24hrs, r2 |
| GSM7784973 |
MINO, GS716054 , 24hrs, r3 |
| GSM7784974 |
MINO, DMSO, 72hrs, r1 |
| GSM7784975 |
MINO, DMSO, 72hrs, r2 |
| GSM7784976 |
MINO, DMSO, 72hrs, r3 |
| GSM7784977 |
MINO, GS716054 , 72hrs, r1 |
| GSM7784978 |
MINO, GS716054 , 72hrs, r2 |
| GSM7784979 |
MINO, GS716054 , 72hrs, r3 |
| GSM7784980 |
UPN-1, DMSO, 24hrs, r1 |
| GSM7784981 |
UPN-1, DMSO, 24hrs, r2 |
| GSM7784982 |
UPN-1, DMSO, 24hrs, r3 |
| GSM7784983 |
UPN-1, GS716054 , 24hrs, r1 |
| GSM7784984 |
UPN-1, GS716054 , 24hrs, r2 |
| GSM7784985 |
UPN-1, GS716054 , 24hrs, r3 |
| GSM7784986 |
UPN-1, DMSO, 72hrs, r1 |
| GSM7784987 |
UPN-1, DMSO, 72hrs, r2 |
| GSM7784988 |
UPN-1, DMSO, 72hrs, r3 |
| GSM7784989 |
UPN-1, GS716054 , 72hrs, r1 |
| GSM7784990 |
UPN-1, GS716054 , 72hrs, r2 |
| GSM7784991 |
UPN-1, GS716054 , 72hrs, r3 |
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| Relations |
| BioProject |
PRJNA1018417 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE243395_RAW.tar |
6.8 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
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