 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Oct 02, 2023 |
| Title |
Single-nucleus RNA sequencing of dorsolateral prefrontal cortex from normal, pathological aging, and Alzheimer’s disease human brains |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We performed single-nucleus RNA sequencing of the dorsolateral prefrontal cortex from 15 normal, pathological aging, and Alzheimer’s disease human brains that varied by APOE and TREM2 genotype to analyze cell-type specific transcriptomic changes across the range of Alzheimer’s disease pathology and genetic risk factors.
|
| |
|
| Overall design |
Nuclei were isolated and sequenced from normal (no amyloid or tau pathology), pathological aging (amyloid pathology without tau pathology), and Alzheimer’s disease (amyloid and tau pathology) human brain tissues that varied by Alzheimer’s disease genetic risk factors (APOE, TREM2).
|
| |
|
| Contributor(s) |
Dai DL, Nguyen AT, Wang K, Hu G, Wang X, Miao Z, Azevedo JA, Suh E, Van Deerlin VM, Choi D, Roeder K, Li M, Lee EB |
| Citation(s) |
32840654, 37589745 |
| |
| Submission date |
Sep 14, 2023 |
| Last update date |
Jul 18, 2024 |
| Contact name |
Edward Lee |
| E-mail(s) |
edward.lee@pennmedicine.upenn.edu
|
| Organization name |
University of Pennsylvania
|
| Street address |
613A Stellar Chance Laboratories; 422 Curie Blvd
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (15)
|
| GSM7782919 |
Brain, Pathology Aging, sample 4 |
| GSM7782920 |
Brain, Pathology Aging, sample 5 |
| GSM7782921 |
Brain, Pathology Aging, sample 6 |
| GSM7782922 |
Brain, Pathology Aging, sample 7 |
| GSM7782923 |
Brain, Alzheimer’s Disease, sample 8 |
| GSM7782924 |
Brain, Alzheimer’s Disease, sample 9 |
| GSM7782925 |
Brain, Alzheimer’s Disease, sample 10 |
| GSM7782926 |
Brain, Alzheimer’s Disease, sample 11 |
| GSM7782927 |
Brain, Alzheimer’s Disease, sample 12 |
| GSM7782928 |
Brain, Alzheimer’s Disease, sample 13 |
| GSM7782929 |
Brain, Alzheimer’s Disease, sample 14 |
| GSM7782930 |
Brain, Alzheimer’s Disease, sample 15 |
|
| Relations |
| BioProject |
PRJNA1017546 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE243292_ADsnRNAseq_GEO.h5ad.gz |
281.3 Mb |
(ftp)(http) |
H5AD |
| GSE243292_Astrocyte_GEO.h5ad.gz |
951.4 Mb |
(ftp)(http) |
H5AD |
| GSE243292_Microglia_GEO.h5ad.gz |
7.2 Mb |
(ftp)(http) |
H5AD |
| GSE243292_processed_data_readme.txt |
680 b |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
|
|
|
|
 |
Less...
More...