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| Status |
Public on Aug 31, 2024 |
| Title |
Single-cell RNA sequencing analysis of peripheral blood mononuclear cells in PD-1-induced renal toxicity in patients with lung cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The purpose of the study was to investigate the potential role of the immune system in renal irAEs by analyzing the features of peripheral blood mononuclear cells (PBMC) from patients with renal irAEs using single-cell RNA sequencing (scRNA-seq).
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| Overall design |
PBMCs were collected from three patients with renal irAEs induced by anti-PD-1 therapy and three patients without renal irAEs. In order to find cell clusters and differentially expressed genes (DEGs), the PBMCs were submitted to scRNA-seq. KEGG and GO analysis were carried out to investigate the most active biological processes in CD4+ T and CD8+ T cells.
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| Contributor(s) |
Liu S, Lu P, Yang B, Yang Y, Zhou H, Yang M |
| Citation(s) |
39277735 |
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| Submission date |
Sep 08, 2023 |
| Last update date |
Oct 09, 2024 |
| Contact name |
Shusu Liu |
| Organization name |
The Third Affiliated Hospital of Soochow University
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| Department |
Department of Nephrology
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| Street address |
No 185，Juqian Road
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| City |
Changzhou |
| ZIP/Postal code |
213003 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1014497 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE242780_RAW.tar |
285.7 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
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