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| Status |
Public on Sep 12, 2023 |
| Title |
Biotransformed Bear Bile Powder Ameliorates Diet-induced Nonalcoholic Steatohepatitis in Mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To evaluate the therapeutic effects and underlying mechanisms of BBBP against NASH
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| Overall design |
There are three sets of samples, namely the Control group, Model group, and BBBPH group (JDH group), with 5 samples in each group.To establish a nonalcoholic steatohepatitis model, mice were fed on a high-fat high- sucrose diet (60% kcal fat, 20% kcal protein, 20% kcal carbohydrates and 0.2% cholesterol, D12492, Research Diets, USA) along with drinking water containing 42 g/L sugar (55% sucrose and 45% fructose by weight) for 20 weeks after which they were sacrificed. After 12 weeks, the high-fat high- sucrose diet-induced nonalcoholic steatohepatitis mice were divided into 2 groups (model and JDH (Biotransformed Bear Bile Powder) group). Then, mice in different groups were orally administered 150 mg/kg Biotransformed Bear Bile Powder (the JDH group, n=14) and saline (the model group) daily, concurrent with the high-fat high- sucrose diet.
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| Contributor(s) |
Jiang S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Sep 07, 2023 |
| Last update date |
Sep 12, 2023 |
| Contact name |
Shan Jiang |
| E-mail(s) |
yc07548@umac.mo
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| Organization name |
China Academy of Chinese Medical Sciences
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| Street address |
No. 16, Nanxiao Road/Street
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| City |
Beijing |
| ZIP/Postal code |
100700 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA1014000 |
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