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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Nov 30, 2023 |
| Title |
Gene expression profile at single cell level of bone marrow mononuclear cells from MDS patients with secondary venetoclax-based therapy failure |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Myelodysplastic syndromes (MDS) are incurable neoplasms that arise from early hematopoietic stem cells (HSCs). We used single cell RNA sequencing (scRNA-seq) to evaluate mechanisms of resistance to venetoclax-based therapies.
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| Overall design |
Bone marrow mononuclear cells were isolated by Fluorescence-activated cell sorting (FACS) and analyzed using scRNAseq.
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| Contributor(s) |
Rodriguez-Sevilla JJ, Ma F, Colla S |
| Citation(s) |
38499526 |
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| Submission date |
Aug 22, 2023 |
| Last update date |
Apr 02, 2024 |
| Contact name |
Feiyang Ma |
| Organization name |
UCLA
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| Department |
Molecular Biology Institute
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| Lab |
Pellegrini Lab
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| Street address |
610, Charles Young Dr East, TLSB 3000C
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| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90095 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (18)
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| GSM7728570 |
BM, C0, UPN#2 |
| GSM7728571 |
BM, C2, UPN#2 |
| GSM7728572 |
BM, C8, UPN#2 |
| GSM7728573 |
BM, C9, UPN#2 |
| GSM7728574 |
BM, C0, UPN#1, replicate 1 |
| GSM7728575 |
BM, C0, UPN#1, replicate 2 |
| GSM7728576 |
BM, C1, UPN#1, replicate 1 |
| GSM7728577 |
BM, C1, UPN#1, replicate 2 |
| GSM7728578 |
BM, C2, UPN#1, replicate 1 |
| GSM7728579 |
BM, C2, UPN#1, replicate 2 |
| GSM7728580 |
BM, C4, UPN#1, replicate 1 |
| GSM7728581 |
BM, C4, UPN#1, replicate 2 |
| GSM7728582 |
BM, C7, UPN#1 |
| GSM7728583 |
BM, C8, UPN#1 |
| GSM7728584 |
BM, C12, UPN#1 |
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| Relations |
| BioProject |
PRJNA1008111 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE241417_RAW.tar |
221.4 Mb |
(http)(custom) |
TAR (of H5) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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