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| Status |
Public on Aug 18, 2024 |
| Title |
Fibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes [RNA-seq: TSP4 OE] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Our study provides the first direct evidence supporting a fibroblast-mediated mechanism of dysfunction and adverse remodeling in the diabetic heart, highlighting the importance of interstitial cells in the pathogenesis of diabetic cardiomyopathy. Diabetes-associated activation of the TGF-b/Smad3 cascade may promote dysfunction not only by accentuating ECM deposition and crosslinking, but also by modulating cardiomyocyte phenotype and function. Thus, the TGF-b system may be a promising therapeutic target in patients with diabetes-associated heart failure.
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| |
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| Overall design |
Comparison of the transcriptomic profile of cardiac fibroblasts with TSP-4 overexpression (4 samples) vs. control (4 samples).
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| |
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| Contributor(s) |
Tuleta I, Sidoli S, Humeres C, Frangogiannis NG |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Aug 18, 2023 |
| Last update date |
Aug 18, 2024 |
| Contact name |
Izabela Tuleta |
| E-mail(s) |
izabela.tuleta@einsteinmed.edu
|
| Phone |
3475159231
|
| Organization name |
Albert Einstein College of Medicine
|
| Department |
Cardiology
|
| Street address |
1300 Morris Park Avenue
|
| City |
NYC |
| State/province |
NY |
| ZIP/Postal code |
10461 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (8)
|
| GSM7718905 |
cardiac fibroblasts with TSP-4 overexpression, A |
| GSM7718906 |
cardiac fibroblasts with TSP-4 overexpression, B |
| GSM7718907 |
cardiac fibroblasts with TSP-4 overexpression, C |
| GSM7718908 |
cardiac fibroblasts with TSP-4 overexpression, D |
| GSM7718909 |
non-stimulated cardiac fibroblasts, A |
| GSM7718910 |
non-stimulated cardiac fibroblasts, B |
| GSM7718911 |
non-stimulated cardiac fibroblasts, C |
| GSM7718912 |
non-stimulated cardiac fibroblasts, D |
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| This SubSeries is part of SuperSeries: |
| GSE241180 |
Fibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes |
|
| Relations |
| BioProject |
PRJNA1006688 |
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