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| Status |
Public on Aug 18, 2024 |
| Title |
Fibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes [RNA-seq: Smad3 in dbdb] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Our study provides the first direct evidence supporting a fibroblast-mediated mechanism of dysfunction and adverse remodeling in the diabetic heart, highlighting the importance of interstitial cells in the pathogenesis of diabetic cardiomyopathy. Diabetes-associated activation of the TGF-b/Smad3 cascade may promote dysfunction not only by accentuating ECM deposition and crosslinking, but also by modulating cardiomyocyte phenotype and function. Thus, the TGF-b system may be a promising therapeutic target in patients with diabetes-associated heart failure.
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| Overall design |
Comparison of the transcriptomic profile of cardiac fibroblasts from Smad3KO vs. Smad3 lean and db/db animals. 3 samples per group (12 samples in total).
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| Contributor(s) |
Tuleta I, Sidoli S, Humeres C, Frangogiannis NG |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Aug 18, 2023 |
| Last update date |
Aug 18, 2024 |
| Contact name |
Izabela Tuleta |
| E-mail(s) |
izabela.tuleta@einsteinmed.edu
|
| Phone |
3475159231
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| Organization name |
Albert Einstein College of Medicine
|
| Department |
Cardiology
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| Street address |
1300 Morris Park Avenue
|
| City |
NYC |
| State/province |
NY |
| ZIP/Postal code |
10461 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (12)
|
| GSM7718886 |
cardiac fibroblasts from Smad3 fl/fl db/db animals, 1 |
| GSM7718887 |
cardiac fibroblasts from Smad3 fl/fl db/db animals, 2 |
| GSM7718888 |
cardiac fibroblasts from Smad3 fl/fl db/db animals, 3 |
| GSM7718889 |
cardiac fibroblasts from Smad3 fl/fl lean animals, 1 |
| GSM7718890 |
cardiac fibroblasts from Smad3 fl/fl lean animals, 2 |
| GSM7718891 |
cardiac fibroblasts from Smad3 fl/fl lean animals, 3 |
| GSM7718892 |
cardiac fibroblasts from Smad3 KO db/db animals, 1 |
| GSM7718893 |
cardiac fibroblasts from Smad3 KO db/db animals, 2 |
| GSM7718894 |
cardiac fibroblasts from Smad3 KO db/db animals, 3 |
| GSM7718895 |
cardiac fibroblasts from Smad3 KO lean animals, 1 |
| GSM7718896 |
cardiac fibroblasts from Smad3 KO lean animals, 2 |
| GSM7718897 |
cardiac fibroblasts from Smad3 KO lean animals, 3 |
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| This SubSeries is part of SuperSeries: |
| GSE241180 |
Fibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes |
|
| Relations |
| BioProject |
PRJNA1006685 |
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