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| Status |
Public on May 17, 2024 |
| Title |
Role of reducing Hmbox1 in cardiac ischemia/reperfusion injury |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
This RNA-sequencing was performed to determine the differentially expressed mRNA after inhibition of Hmbox1 in cardiac ischemia/reperfusion injury
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| Overall design |
To investigate the function of Hmbox1 in cardiac ischemia/reperfusion (I/R) injury, we established cardiac I/R injury mouse model in which Hmbox1 was knocked down via adeno-associated virus 9 (AAV9). Total RNAs were extracted from heart tissues from mice at 3 weeks post I/R injury. Four groups were set in this animal experiment (n=3 per group): (1) control AAV9+Sham (Con_Sham); (2) sh-Hmbox1 AAV9+Sham (shHmbox1_Sham); (3) control AAV9+IRI (Con_IRI); (4) sh-Hmbox1 AAV9+IRI (shHmbox1_IRI). The mRNA expression profiling analyses were performed using data obtained from RNA-seq of 4 different groups.
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| Contributor(s) |
Xiao J, Bei Y, Zhu Y |
| Citation(s) |
38708602 |
| |
| Submission date |
Aug 17, 2023 |
| Last update date |
May 17, 2024 |
| Contact name |
Yujiao Zhu |
| E-mail(s) |
zhu1yu2jiao3@i.shu.edu.cn
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| Phone |
18817602272
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| Organization name |
Shanghai University
|
| Street address |
Nanchen Road 381
|
| City |
shanghai |
| ZIP/Postal code |
200044 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA1006367 |
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