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| Status |
Public on Sep 18, 2023 |
| Title |
Whole genome microarray gene expression profiling of transgenic mouse hearts with four-fold increased BBLN contents |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The study performed whole genome microarray gene expression profiling of mouse hearts from BBLN-transgenic mice with four-fold increased cardiac BBLN (Bublin coiled coil protein) contents (Tg-BBLN-low) in comparison to non-transgenic FVB hearts. Tg-BBLN-low mice with four-fold increased cardiac BBLN expression under control of the myocardium-specific alpha-MHC promoter developed features of compensated heart failure with increasing age, which was characterized by a significantly reduced left ventricular ejection fraction as determined by echocardiography. To investigate the compensated heart failure phenotype of Tg-BBLN-low mice, whole genome micoarray gene expression profiling was performed. The microarray data show that moderately increased cardiac BBLN levels are sufficient to induce features of pathological cardiac remodeling.
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| Overall design |
Whole genome microarray gene expression profiling was performed of mouse hearts from BBLN-transgenic mice with four-fold increased BBLN-contents. Hearts were isolated from eight-month-old, male Tg-BBLN-low mice and from male, age-matched non-transgenic FVB mice, which were used as controls.
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| Contributor(s) |
Abd Alla J, Quitterer U |
| Citation(s) |
38666071 |
| |
| Submission date |
Aug 16, 2023 |
| Last update date |
May 10, 2024 |
| Contact name |
Ursula Quitterer |
| E-mail(s) |
ursula.quitterer@pharma.ethz.ch
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| Phone |
+41-446329801
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| Organization name |
ETH Zurich
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| Department |
Molecular Pharmacology
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| Street address |
Winterthurerstrasse 190
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| City |
Zurich |
| ZIP/Postal code |
CH-8057 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA1006074 |
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