GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE23989 Query DataSets for GSE23989
Status Public on Dec 31, 2014
Title Global gene expression in Head and neck squamous carcinoma (KB) cells treated with the combination of 2-DG + 6-AN followed by irradiation (2-Gy)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Whole genome expression profiling of head and neck squamous carcinoma (KB) cells comparing control untreated cells as well as irradited (2 Gy) alone cells with carcinoma cells treated with the combination of 2-DG and 6-AN followed by irradiation (2 Gy). Goal of this study was to study the global gene expression involved in radiosensitization of Head and neck squamous carcinoma (KB cells) treated with the combination of two metabolic modifers namely 2-deoxy-D-Glucose (2-DG) and 6-Aminonicotinamide (6-AN) followed by irradiation (2 Gy). This will enable us to understand the role of metabolic oxidative stress (MOS) involved in the radiosensitization of cancer cells and regulation between complex molecular circuits to develop better therapeutic approaches/ protection against oxidative damage.
Overall design Agilent two-color experiment, Organism: Human, Agilent-14850 Agilent Whole Genome Human 4x44k (AMADID No: 14850), Labeling kit: Agilent Low RNA Input Linear amplification Kit (Part number:5184-3523)
Contributor(s) Sharma PK, bhardwaj R, Pathak R, Dwarakanath BS, Raghuram N, Varshney R
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Sep 07, 2010
Last update date Feb 22, 2018
Contact name Pradeep Sharma
Organization name Institute of Nuclear medicine and allied sciences (INMAS, DRDO)
Department Division of radiation biosciences
Street address Lucknow Road, Timarpur
City New Delhi
State/province Delhi
ZIP/Postal code 110054
Country India
Platforms (1)
GPL4133 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
Samples (4)
GSM590901 Experiment 1
GSM590902 Experiment 2
GSM590903 Experiment 3
BioProject PRJNA130487

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE23989_RAW.tar 68.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap