GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE239391 Query DataSets for GSE239391
Status Public on May 03, 2024
Title Single-cell RNA sequencing Reveals Obesity-Induced Inhibition of Testosterone Production and Damage of Blood-Testis Barrier Integrity
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Obesity is accompanied by multiple known health risks and increased morbidity, and the prevalence of obesity continues to rise. Fertility in males of reproductive age is affected by the endocrine abnormalities and comorbidities associated with obesity, which has become a primary cause of male infertility. Single-cell RNA sequencing (scRNA-seq) of testes in obese individuals has not been done, so we chose to use this technique to study the mechanism of infertility in an obese mouse model.
Overall design Male ICR mice were randomly divided into a conventional diet (CD) group and a high-fat diet (HFD) group at the age of 6 weeks. Testes of the two groups were collected and analyzed by scRNA-seq.
Contributor(s) Qu P
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Jul 27, 2023
Last update date May 04, 2024
Contact name Wenbin Cao
Organization name Xi'an Jiaotong University
Street address 76 Yanta West Road, Xi’an, Shaanxi 710061, China
City Xi'an
State/province Shanxi
ZIP/Postal code 710061
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (6)
GSM7664011 CD, replicated 1, scRNA-seq
GSM7664012 CD, replicated 2, scRNA-seq
GSM7664013 CD, replicated 3, scRNA-seq
BioProject PRJNA999209

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE239391_RAW.tar 1.1 Gb (http)(custom) TAR (of MTX, TAR, TSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap