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| Status |
Public on May 03, 2024 |
| Title |
Single-cell RNA sequencing Reveals Obesity-Induced Inhibition of Testosterone Production and Damage of Blood-Testis Barrier Integrity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Obesity is accompanied by multiple known health risks and increased morbidity, and the prevalence of obesity continues to rise. Fertility in males of reproductive age is affected by the endocrine abnormalities and comorbidities associated with obesity, which has become a primary cause of male infertility. Single-cell RNA sequencing (scRNA-seq) of testes in obese individuals has not been done, so we chose to use this technique to study the mechanism of infertility in an obese mouse model.
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| Overall design |
Male ICR mice were randomly divided into a conventional diet (CD) group and a high-fat diet (HFD) group at the age of 6 weeks. Testes of the two groups were collected and analyzed by scRNA-seq.
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| Contributor(s) |
Qu P |
| Citation(s) |
38834587 |
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| Submission date |
Jul 27, 2023 |
| Last update date |
Jun 26, 2024 |
| Contact name |
Wenbin Cao |
| E-mail(s) |
caowenbin@stu.xjtu.edu.cn
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| Organization name |
Xi'an Jiaotong University
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| Street address |
76 Yanta West Road, Xi’an, Shaanxi 710061, China
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| City |
Xi'an |
| State/province |
Shanxi |
| ZIP/Postal code |
710061 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA999209 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE239391_RAW.tar |
1.1 Gb |
(http)(custom) |
TAR (of MTX, TAR, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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