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| Status |
Public on Jul 19, 2023 |
| Title |
Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The deficiency of n-3 PUFAs in the brain and depressive symptoms are closely related. Krill oil contains abundant amounts of n-3 PUFAs incorporated in phosphatidylcholine.However, the effect of krill oil treatment on depression-like behaviors induced by chronic stress and its molecular mechanism in the brain remain poorly understood. Here, we used a chronic unpredictable mild stress (CUMS) model to evaluate the effect of krill oil on depression-like behaviors and explored its molecular mechanism through lipid metabolomics and mRNA profiles in the whole brain.
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| Overall design |
Brains of four differently treated C57/BL6J mice, control group, krill oil group, CUMS group and CUMS+krill oil group
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| Contributor(s) |
Zhang H, Song Z |
| Citation missing |
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| |
| Submission date |
Jul 19, 2023 |
| Last update date |
Jul 19, 2023 |
| Contact name |
Hao Zhang |
| E-mail(s) |
2020021138@qdu.edu.cn
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| Organization name |
Qingdao University School of Pharmacy
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| Street address |
38 Dengzhou, Qingdao Shandong China
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| City |
Qingdao |
| ZIP/Postal code |
266021 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA996562 |
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