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| Status |
Public on Dec 08, 2023 |
| Title |
USP2 inhibition prevents infection with ACE2- dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In this study, we identified USP2 as a physiological deubiquitinase of ACE2 and USP2 inhibition led to ACE2 protein destruction, thereby preventing infections of coronaviruses that reliant on ACE2
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| Overall design |
RNA-seq study of lung samples derived from K18-hACE2 mice infected with SARS-CoV-2 (Wuhan strain) and subjected to the treatment of vehicle control or USP2 inhibitor ML364
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| Contributor(s) |
Dang F, Bai L, Lan K, Wei W |
| Citation(s) |
38055802 |
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| Submission date |
Jul 19, 2023 |
| Last update date |
Dec 08, 2023 |
| Contact name |
Fabin Dang |
| E-mail(s) |
fdang@bidmc.harvard.edu
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| Organization name |
Beth Israel Deaconess Medical Center
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| Street address |
3 Blackfan Circle
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| City |
Boston |
| ZIP/Postal code |
02215 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA996524 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE237741_Raw_Gene_Expression.csv.gz |
4.8 Mb |
(ftp)(http) |
CSV |
| GSE237741_Vehicle_vs_ML364.DESeq.csv.gz |
3.6 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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