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| Status |
Public on Jul 16, 2023 |
| Title |
RNA-seq analysis of Lrig1+ and Lrig1- CD4+ T cells in mouse spleen |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Regulatory T cell (Treg) is the immune-suppressive T cell subset and the crucial component for preventing autoimmunity. The molecules defining the suppressive population of T cells phenotypically and functionally remain to be discovered.
In this study, we report that Lrig1 is highly expressed in suppressive CD4+ T cell populations. We performed RNA-seq analysis of CD4+Lrig1+ and CD4+Lrig1- T cells from mouse splenocytes to analyze the genes involeved in the suppressive function of T cells.
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| Overall design |
To investigate the transcriptional difference between Lrig1+ and Lrig1- CD4+ T cells, we isolated Lrig1+ and Lrig1- CD4+ T cells from spleen of 7 weeks of age female C57BL/6 mice using flow cytometry.
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| Contributor(s) |
Lee S, Moon J, Ho C, Lee S |
| Citation(s) |
37666819 |
| |
| Submission date |
Jul 10, 2023 |
| Last update date |
Sep 15, 2023 |
| Contact name |
Chun-Chang Ho |
| E-mail(s) |
gnwnsckd93@naver.com
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| Organization name |
Good T cells.,Inc.
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| Street address |
189 Seongam-ro
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| City |
Seoul |
| ZIP/Postal code |
03929 |
| Country |
South Korea |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA993251 |
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