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| Status |
Public on Aug 08, 2024 |
| Title |
Tumor cell-intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Piezo2 impedes stemness maintenance of CD8+ T cells by downregulating IL-15 production after radiotherapy, thereby leading to cancer radioresistance.
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| Overall design |
MC38-WT tumor cells were subjected to single fraction of X-ray (30 Gy). 60 hours later, total RNA from samples was extracted using Trizol Reagent following standard protocols and mRNA sequencing was performed.
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| Contributor(s) |
Li W |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 03, 2023 |
| Last update date |
Aug 08, 2024 |
| Contact name |
Wenwen Li |
| E-mail(s) |
wenwenli2016@sjtu.edu.cn
|
| Organization name |
Shanghai Institute of Immunology; Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine
|
| Street address |
Room 1004, West #5 Building, 280 South Chongqing Road, Shanghai 200025, China
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| City |
Shanghai |
| ZIP/Postal code |
200025 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE236346 |
Piezo2 promotes resistance to radiation by suppressing CD8+ T cell-mediated antitumor immunity via IRF-1/IL-15 signaling |
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| Relations |
| BioProject |
PRJNA990662 |
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