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| Status |
Public on Apr 03, 2024 |
| Title |
Claudin-1 as a novel target gene induced in obesity and associated to inflammation, fibrosis and cell differentiation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
T-lymphocytes from visceral and subcutaneous white adipose tissue (vWAT and sWAT, respectively) can have opposing roles in the systemic metabolic changes associated with obesity. However, few studies have focused on this subject. Claudin-1 (CLDN1) is a protein involved canonically in Tight Junctions (TJs) and tissue paracellular permeability.
We evaluated the gene expression in T lymphocytes from vWAT and sWAT and in the whole adipose depots.
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| Overall design |
A Clariom D-based transcriptomics analysis was performed in T lymphocytes magnetically separated from vWAT and sWAT from patients with obesity (Cohort 1; N = 11). The experimental design for hybridization processing included 4 batches of 9-11 samples each with balancing among different batches between the two compared conditions: vWAT and sWAT.
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| Contributor(s) |
Fernández-García P, Taxerås SD, Reyes-Farias M, González L, Soria-Gondek A, Pellitero S, Tarascó J, Moreno P, Sumoy L, Stephens JM, Galán M, Izquierdo A, Medina-Gómez G, Herrero L, Corrales P, Villarroya F, Cereijo R, Sánchez-Infantes D |
| Citation(s) |
38544694 |
| Submission date |
Jun 29, 2023 |
| Last update date |
Apr 04, 2024 |
| Contact name |
Lauro Sumoy |
| E-mail(s) |
lsumoy@igtp.cat
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| Organization name |
IGTP
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| Department |
High Content Genomics and Bioinformatics
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| Street address |
Ctra. Can Ruti, Camí de les escoles s/n
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| City |
Badalona |
| State/province |
Barcelona |
| ZIP/Postal code |
08916 |
| Country |
Spain |
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| Platforms (1) |
| GPL23126 |
[Clariom_D_Human] Affymetrix Human Clariom D Assay [transcript (gene) version] |
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| Samples (22)
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| GSM7518821 |
T lymphocytes, vWAT infiltrating, obese individual 1 |
| GSM7518822 |
T lymphocytes, sWAT infiltrating, obese individual 1 |
| GSM7518823 |
T lymphocytes, vWAT infiltrating, obese individual 2 |
| GSM7518824 |
T lymphocytes, sWAT infiltrating, obese individual 2 |
| GSM7518825 |
T lymphocytes, vWAT infiltrating, obese individual 3 |
| GSM7518826 |
T lymphocytes, sWAT infiltrating, obese individual 3 |
| GSM7518827 |
T lymphocytes, vWAT infiltrating, obese individual 4 |
| GSM7518828 |
T lymphocytes, sWAT infiltrating, obese individual 4 |
| GSM7518829 |
T lymphocytes, vWAT infiltrating, obese individual 5 |
| GSM7518830 |
T lymphocytes, sWAT infiltrating, obese individual 5 |
| GSM7518831 |
T lymphocytes, vWAT infiltrating, obese individual 6 |
| GSM7518832 |
T lymphocytes, sWAT infiltrating, obese individual 6 |
| GSM7518833 |
T lymphocytes, vWAT infiltrating, obese individual 7 |
| GSM7518834 |
T lymphocytes, sWAT infiltrating, obese individual 7 |
| GSM7518835 |
T lymphocytes, vWAT infiltrating, obese individual 8 |
| GSM7518836 |
T lymphocytes, sWAT infiltrating, obese individual 8 |
| GSM7518837 |
T lymphocytes, vWAT infiltrating, obese individual 9 |
| GSM7518838 |
T lymphocytes, sWAT infiltrating, obese individual 9 |
| GSM7518839 |
T lymphocytes, vWAT infiltrating, obese individual 10 |
| GSM7518840 |
T lymphocytes, sWAT infiltrating, obese individual 10 |
| GSM7518841 |
T lymphocytes, vWAT infiltrating, obese individual 11 |
| GSM7518842 |
T lymphocytes, sWAT infiltrating, obese individual 11 |
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| Relations |
| BioProject |
PRJNA989130 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE236145_RAW.tar |
521.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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