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| Status |
Public on Jun 30, 2024 |
| Title |
REGULATION OF WHOLE-TRANSCRIPTOME SEQUENCING EXPRESSION IN COPD AFTER PERSONALIZED PRECISE EXERCISE TRAINING: A PILOT STUDY |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Aerobic exercise, the cornerstone of pulmonary rehabilitation, improves prognosis of COPD patients; however, few studies have comprehensively examined the changes in RNA transcript levels and the crosstalk between various transcripts in this context. This study identified the expression of RNA transcripts in COPD patients who engaged in aerobic exercise training for 12 weeks, and further constructions of the possible RNAs networks were made.
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| Overall design |
Peripheral blood white blood cell samples for all four COPD patients who benefited from 12 weeks of PR were collected pre- and post-aerobic exercises and evaluated for the expression of mRNA, miRNA, lncRNA, and circRNA with high-throughput RNA sequencing followed by GEO date validation. In addition, enrichment analyses were conducted on different expressed mRNAs. LncRNA-mRNA and circRNA-mRNA coexpression networks, as well as lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA competing expression networks (ceRNAs) in COPD were constructed.
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| Contributor(s) |
liu p, zhang m, zhao l, sun x |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Jun 16, 2023 |
| Last update date |
Jun 30, 2024 |
| Contact name |
panpan liu |
| E-mail(s) |
liup202309@outlook.com
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| Phone |
008613817534495
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| Organization name |
shanghai pudong new area gongli hospital
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| Street address |
No219,MiaoPU Road
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| City |
shanghai |
| ZIP/Postal code |
200135 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA984709 |
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